Linked 4-Way Multimodal Brain Differences in Schizophrenia in a Large Chinese Han Population

doi:10.1093/schbul/sby045

	Linked 4-Way Multimodal Brain Differences in Schizophrenia in a Large Chinese Han Population
	Liu, Shengfeng1,2,3,4,5 ; Wang, Haiying 3; Song, Ming1,2 ; Lv, Luxian 6,7; Cui, Yue1,2 ; Liu, Yong1,2 ; Fan, Lingzhong1,2 ; Zuo, Nianming1,2 ; Xu, Kaibin1,2 ; Du, Yuhui 8,9
刊名	SCHIZOPHRENIA BULLETIN
	2019-03-01
卷号	45 期号:2 页码:436-449
关键词	multimodal fusion resting-state fMRI schizophrenia auditory hallucination functional network connectivity (FNC) structural MRI diffusion MRI MCCA plus jICA
ISSN号	0586-7614
DOI	10.1093/schbul/sby045
通讯作者	Sui, Jing(jing.sui@nlpr.ia.ac.cn)
英文摘要	Multimodal fusion has been regarded as a promising tool to discover covarying patterns of multiple imaging types impaired in brain diseases, such as schizophrenia (SZ). In this article, we aim to investigate the covarying abnormalities underlying SZ in a large Chinese Han population (307 SZs, 298 healthy controls [HCs]). Four types of magnetic resonance imaging (MRI) features, including regional homogeneity (ReHo) from resting-state functional MRI, gray matter volume (GM) from structural MRI, fractional anisotropy (FA) from diffusion MRI, and functional network connectivity (FNC) resulted from group independent component analysis, were jointly analyzed by a data-driven multivariate fusion method. Results suggest that a widely distributed network disruption appears in SZ patients, with synchronous changes in both functional and structural regions, especially the basal ganglia network, salience network (SAN), and the frontoparietal network. Such a multimodal coalteration was also replicated in another independent Chinese sample (40 SZs, 66 HCs). Our results on auditory verbal hallucination (AVH) also provide evidence for the hypothesis that prefrontal hypoactivation and temporal hyperactivation in SZ may lead to failure of executive control and inhibition, which is relevant to AVH. In addition, impaired working memory performance was found associated with GM reduction and FA decrease in SZ in prefrontal and superior temporal area, in both discovery and replication datasets. In summary, by leveraging multiple imaging and clinical information into one framework to observe brain in multiple views, we can integrate multiple inferences about SZ from large-scale population and offer unique perspectives regarding the missing links between the brain function and structure that may not be achieved by separate unimodal analyses.
资助项目	Chinese National Science Foundation[81471367] ; Chinese National Science Foundation[61773380] ; Chinese National Science Foundation[61703253] ; National High-Tech Development Plan (863 program)[2015AA020513] ; 100 Talents Plan of Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB02060005] ; Natural Science Foundation of Shanxi[2016021077] ; NIH[R01EB005846] ; NIH[1R01MH094524] ; NIH[P20GM103472]
WOS关键词	AUDITORY HALLUCINATIONS ; FUNCTIONAL CONNECTIVITY ; 1ST-EPISODE SCHIZOPHRENIA ; WHITE-MATTER ; GRAY-MATTER ; ANTIPSYCHOTIC TREATMENT ; BIPOLAR DISORDER ; WORKING-MEMORY ; DIGIT SPAN ; FUSION
WOS研究方向	Psychiatry
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000461163300023
资助机构	Chinese National Science Foundation ; National High-Tech Development Plan (863 program) ; 100 Talents Plan of Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Natural Science Foundation of Shanxi ; NIH
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/24992]
专题	中国科学院自动化研究所
通讯作者	Sui, Jing
作者单位	1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Harbin Univ Sci & Technol, Sch Automat, Harbin, Heilongjiang, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Shenzhen Univ, Sch Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasoun, Natl Reg Key Technol Engn Lab Med Ultrasound, Shenzhen, Peoples R China 6.Xinxiang Med Univ, Affiliated Hosp 2, Henan Mental Hosp, Dept Psychiat, Xinxiang, Peoples R China 7.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Peoples R China 8.Mind Res Network, Albuquerque, NM USA 9.Shanxi Univ, Sch Comp & Informat Technol, Taiyuan, Shanxi, Peoples R China 10.Beijing Inst Technol, Sch Opt & Elect, Beijing Engn Res Ctr Mixed Real & Adv Display, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Liu, Shengfeng,Wang, Haiying,Song, Ming,et al. Linked 4-Way Multimodal Brain Differences in Schizophrenia in a Large Chinese Han Population[J]. SCHIZOPHRENIA BULLETIN,2019,45(2):436-449.
APA	Liu, Shengfeng.,Wang, Haiying.,Song, Ming.,Lv, Luxian.,Cui, Yue.,...&Sui, Jing.(2019).Linked 4-Way Multimodal Brain Differences in Schizophrenia in a Large Chinese Han Population.SCHIZOPHRENIA BULLETIN,45(2),436-449.
MLA	Liu, Shengfeng,et al."Linked 4-Way Multimodal Brain Differences in Schizophrenia in a Large Chinese Han Population".SCHIZOPHRENIA BULLETIN 45.2(2019):436-449.