Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers

doi:10.3389/fphys.2018.00836

CORC > 海洋研究所 > 中国科学院海洋研究所 > 海洋生态与环境科学重点实验室

	Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers
	Sun, Lina 1; Lin, Chenggang 1; Li, Xiaoni 1; Xing, Lili1 ; Huo, Da 1; Sun, Jingchun1 ; Zhang, Libin 1; Yang, Hongsheng1
刊名	FRONTIERS IN PHYSIOLOGY
	2018-07-03
卷号	9
关键词	sea cucumber intestine regeneration phosphoproteomics acetyl proteomics posttranslational modification
ISSN号	1664-042X
DOI	10.3389/fphys.2018.00836
文献子类	Article
英文摘要	Sea cucumbers exposed to stressful circumstances eviscerate most internal organs, and then regenerate them rapidly under favorable environments. Reversible protein phosphorylation and acetylation are major modifications regulating protein function. Herein, for the first time, we perform quantitative phospho- and acetyl proteomics analyses of intestine regeneration in a sea cucumber species Apostichopus japonicus. We identified 1,862 phosphorylation sites in 1,169 proteins, and 712 acetylation sites in 470 proteins. Of the 147 and 251 proteins differentially modified by phosphorylation and acetylation, respectively, most were related to cytoskeleton biogenesis, protein synthesis and modification, signal recognition and transduction, energy production and conversion, or substance transport and metabolism. Phosphorylation appears to play a more important role in signal recognition and transduction than acetylation, while acetylation is of greater importance in posttranslational modification, protein turnover, chaperones; energy production and conversion; amino acid and lipid transport and metabolism. These results expanded our understanding of the regulatory mechanisms of posttranslational modifications in intestine regeneration of sea cucumbers after evisceration.
学科主题	Physiology
WOS研究方向	Physiology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000437211600002
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/157552]
专题	海洋研究所_海洋生态与环境科学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Sun, Lina,Lin, Chenggang,Li, Xiaoni,et al. Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers[J]. FRONTIERS IN PHYSIOLOGY,2018,9.
APA	Sun, Lina.,Lin, Chenggang.,Li, Xiaoni.,Xing, Lili.,Huo, Da.,...&Yang, Hongsheng.(2018).Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers.FRONTIERS IN PHYSIOLOGY,9.
MLA	Sun, Lina,et al."Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers".FRONTIERS IN PHYSIOLOGY 9(2018).