The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity

doi:10.1016/j.ijbiomac.2017.07.089

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity
	Jin, Weihua 1,2; Zhang, Wenjing1,3 ; Liu, Ge 1; Yao, Jianting 1; Shan, Tifeng 1; Sun, Chaomin 1,4; Zhang, Quanbin 1,4
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2017-12-01
卷号	105 页码:686-692
关键词	Heteropolysaccharide Anti-tumor activity Sargassum thunbergii Structure-activity relationship
ISSN号	0141-8130
DOI	10.1016/j.ijbiomac.2017.07.089
通讯作者	Sun, Chaomin(sunchaomin@qdio.ac.cn) ; Zhang, Quanbin(qbzhang@qdio.ac.cn)
英文摘要	Polysaccharides derived from Sargassum thunbergii were prepared to investigate the structure-activity relationship between polysaccharides and anti-tumor activity in vitro. Many factors were examined. Overall, STW (polysaccharide extracted by hot water) had the best activity, followed by STJ (polysaccharide extracted by dilute alkali), and then STA (polysaccharide extracted by dilute acid). Location of algae had no effect at 500 mu g/mL and 1000 mu g/mL, while STW-QD (algae collected from Qingdao, China) had the best activity, followed by STW-WZ (algae collected from Wenzhou, China) and STW-LJ (algae collected from Lianjiang, China) and then STW-DL (algae collected from Dalian, China) and STW-RC (algae collected from Rongcheng, China) at 250 mu g/mL. Moreover, molecular weight had no effect at 1000 mu g/mL, while higher molecular weights were associated with better activities at 250 mu g/mL and 500 mu g/mL. Sulfate content had no effect at 1000 mu g/mL, while anti-tumor activities decreased accompanying with the changes of sulfate content. Uronic acid content was an important factor influencing activity. The fractions of STW showed little anti-tumor activity; however, the mixture of the fractions of STW showed approximately 60% inhibition. Overall, these findings suggested that the anti-tumor activity of polysaccharides required multilateral cooperation and that some of the effective components were lost. (C) 2017 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[41506165] ; Shandong Provincial Natural Science Foundation, China[ZR2014DQ024] ; Science and Technology program of applied basic research projects of Qingdao Municipal[15-9-1-74-jch] ; Ocean Public Welfare Scientific Research Project ; State Oceanic Administration of the People's Republic of China[201405040]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000414882900077
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/157278]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Sun, Chaomin; Zhang, Quanbin
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310014, Zhejiang, Peoples R China 3.Zhejiang Univ, Sch Basic Med Sci, Hangzhou 310058, Zhejiang, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Jin, Weihua,Zhang, Wenjing,Liu, Ge,et al. The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,105:686-692.
APA	Jin, Weihua.,Zhang, Wenjing.,Liu, Ge.,Yao, Jianting.,Shan, Tifeng.,...&Zhang, Quanbin.(2017).The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,105,686-692.
MLA	Jin, Weihua,et al."The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 105(2017):686-692.