Non-coding RNAs Function as Immune Regulators in Teleost Fish

doi:10.3389/fimmu.2018.02801

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Non-coding RNAs Function as Immune Regulators in Teleost Fish
	Wang, Man 1; Jiang, Shuai 2; Wu, Wei 1; Yu, Fei 1; Chang, Wenguang 1; Li, Peifeng 1; Wang, Kun 1
刊名	FRONTIERS IN IMMUNOLOGY
	2018-11-28
卷号	9 页码:15
关键词	non-coding RNA fish infectious pathogen immune response immune regulator
ISSN号	1664-3224
DOI	10.3389/fimmu.2018.02801
通讯作者	Li, Peifeng(peifli@qdu.edu.cn) ; Wang, Kun(wangk696@163.com)
英文摘要	Non-coding RNAs (ncRNAs) are functional RNA molecules that are transcribed from DNA but not translated into proteins. ncRNAs function as key regulators of gene expression and chromatin modification. Recently, the functional role of ncRNAs in teleost fish has been extensively studied. Teleost fish are a highly diverse group among the vertebrate lineage. Fish are also important in terms of aquatic ecosystem, food production and human life, being the source of animal proteins worldwide and models of biomedical research. However, teleost fish always suffer from the invasion of infectious pathogens including viruses and bacteria, which has resulted in a tremendous economic loss to the fishing industry worldwide. Emerging evidence suggests that ncRNAs, especially miRNAs and lncRNAs, may serve as important regulators in cytokine and chemokine signaling, antigen presentation, complement and coagulation cascades, and T cell response in teleost fish. In this review, we summarize current knowledge and understanding of the roles of both miRNAs and lncRNAs in immune regulation in teleost fish. Molecular mechanism insights into the function of ncRNAs in fish immune response may contribute to the development of potential biomarkers and therapeutic targets for the prevention and treatment of fish diseases.
资助项目	National Natural Science Foundation of China[81701991] ; Applied Basic Research Programs of Qingdao, China[17-1-1-59-jch]
WOS研究方向	Immunology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000451665000002
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/156139]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Li, Peifeng; Wang, Kun
作者单位	1.Qingdao Univ, Med Coll, Inst Translat Med, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Wang, Man,Jiang, Shuai,Wu, Wei,et al. Non-coding RNAs Function as Immune Regulators in Teleost Fish[J]. FRONTIERS IN IMMUNOLOGY,2018,9:15.
APA	Wang, Man.,Jiang, Shuai.,Wu, Wei.,Yu, Fei.,Chang, Wenguang.,...&Wang, Kun.(2018).Non-coding RNAs Function as Immune Regulators in Teleost Fish.FRONTIERS IN IMMUNOLOGY,9,15.
MLA	Wang, Man,et al."Non-coding RNAs Function as Immune Regulators in Teleost Fish".FRONTIERS IN IMMUNOLOGY 9(2018):15.