Reduced default mode network functional connectivity in patients with recurrent major depressive disorder
Yan, Chao-Gan1,2,3,4,5; Chen, Xiao1,2; Li, Le1,2; Castellanos, Francisco Xavier5,6; Bai, Tong-Jian7; Bo, Qi-Jing8; Cao, Jun9; Chen, Guan-Mao10; Chen, Ning-Xuan1,2; Chen, Wei11
刊名PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2019-04-30
卷号116期号:18页码:9078-9083
关键词default mode network functional connectivity major depressive disorder resting-state fMRI REST-meta-MDD
ISSN号0027-8424
DOI10.1073/pnas.1900390116
产权排序1
文献子类article
英文摘要

Major depressive disorder (MDD) is common and disabling, but its neuropathophysiology remains unclear. Most studies of functional brain networks in MDD have had limited statistical power and data analysis approaches have varied widely. The REST-meta-MDD Project of resting-state fMRI (R-fMRI) addresses these issues. Twenty-five research groups in China established the REST-meta-MDD Consortium by contributing R-fMRI data from 1,300 patients with MDD and 1,128 normal controls (NCs). Data were preprocessed locally with a standardized protocol before aggregated group analyses. We focused on functional connectivity (FC) within the default mode network (DMN), frequently reported to be increased in MDD. Instead, we found decreased DMN FC when we compared 848 patients with MDD to 794 NCs from 17 sites after data exclusion. We found FC reduction only in recurrent MDD, not in first-episode drug-naive MDD. Decreased DMN FC was associated with medication usage but not with MDD duration. DMN FC was also positively related to symptom severity but only in recurrent MDD. Exploratory analyses also revealed alterations in FC of visual, sensory-motor, and dorsal attention networks in MDD. We confirmed the key role of DMN in MDD but found reduced rather than increased FC within the DMN. Future studies should test whether decreased DMN FC mediates response to treatment. All R-fMRI indices of data contributed by the REST-meta-MDD consortium are being shared publicly via the R-fMRI Maps Project.

资助项目National Key R&D Program of China[2017YFC1309902] ; National Natural Science Foundation of China[81671774] ; National Natural Science Foundation of China[81630031] ; National Natural Science Foundation of China[81471740] ; National Natural Science Foundation of China[81621003] ; National Natural Science Foundation of China[81371488] ; Hundred Talents Program ; 13th Five-Year Informatization Plan of the Chinese Academy of Sciences[XXH13505] ; Beijing Municipal Science & Technology Commission[Z161100000216152] ; Beijing Municipal Science & Technology Commission[Z171100000117016] ; Beijing Municipal Science & Technology Commission[Z161100002616023] ; Beijing Municipal Science & Technology Commission[Z171100000117012] ; Department of Science and Technology, Zhejiang Province[2015C03037] ; National Basic Research (973) Program[2015CB351702]
WOS关键词CINGULATE CORTEX ; METAANALYSIS ; FAILURE
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATL ACAD SCIENCES
WOS记录号WOS:000466446500064
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Hundred Talents Program ; 13th Five-Year Informatization Plan of the Chinese Academy of Sciences ; Beijing Municipal Science & Technology Commission ; Department of Science and Technology, Zhejiang Province ; National Basic Research (973) Program
内容类型期刊论文
源URL[http://ir.psych.ac.cn/handle/311026/29009]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Yan, Chao-Gan; Zhao, Jing-Ping; Zang, Yu-Feng
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Res Ctr Lifespan Dev Mind & Brain, Beijing 100101, Peoples R China
5.NYU, Sch Med, Dept Child & Adolescent Psychiat, New York, NY 10016 USA
6.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
7.Anhui Med Univ, Hefei 230022, Anhui, Peoples R China
8.Capital Med Univ, Beijing Anding Hosp, Beijing 100054, Peoples R China
9.Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing 400016, Peoples R China
10.Jinan Univ, Affiliated Hosp 1, Guangzhou 510630, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Yan, Chao-Gan,Chen, Xiao,Li, Le,et al. Reduced default mode network functional connectivity in patients with recurrent major depressive disorder[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2019,116(18):9078-9083.
APA Yan, Chao-Gan.,Chen, Xiao.,Li, Le.,Castellanos, Francisco Xavier.,Bai, Tong-Jian.,...&Zang, Yu-Feng.(2019).Reduced default mode network functional connectivity in patients with recurrent major depressive disorder.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,116(18),9078-9083.
MLA Yan, Chao-Gan,et al."Reduced default mode network functional connectivity in patients with recurrent major depressive disorder".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116.18(2019):9078-9083.
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