Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells | |
Hao-Fei Yu; Yi-Fen Wang; Ya-Ping Liu; Zi-Feng Yang; Wan-Yi Huang; Xin-Hua Wang; Jing Yang; Xiao-Dong Luo; Afsar Khan; Yun-Li Zhao | |
刊名 | Bioorganic & Medicinal Chemistry |
2018 | |
期号 | 26页码:1776–1783 |
关键词 | Alstoniasidines a And b Sugar Bridged Bisindole Glioma Stem Cells Alstonia Scholaris |
DOI | 10.1016/j.bmc.2018.02.024 |
英文摘要 | Unlike reported bisindoles linked by single bond directly, alstoniasidines A (1) and B (2), from Alstoniascholaris featuring unprecedented skeleton with two indole moieties bridged by a sugar, represented anovel bisindole type having strictosamide-glucopyranose-picraline scaffold. Both compounds exhibitedselective cytotoxicity against human glioma stem cells (GSCs) and induced caspase-3 dependent extrinsicapoptosis by increasing the expression of interleukin 1 (IL-1), tumor necrosis factor (TNF- a ), and thecleaved caspase-3, while damaged the unlimited proliferation and self-renewal capacity of GSCs. Thisfinding might provide new type of leads for the selective killing of human glioma stem cells. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://159.226.149.26:8080/handle/152453/12351] |
专题 | 昆明动物研究所_肿瘤干细胞生物学 |
通讯作者 | Wan-Yi Huang; Xin-Hua Wang |
作者单位 | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, People’s Republic of China 3.Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan 4.University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China 5.Guangzhou Medical University, Guangzhou 511436, People’s Republic of China |
推荐引用方式 GB/T 7714 | Hao-Fei Yu,Yi-Fen Wang,Ya-Ping Liu,et al. Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells[J]. Bioorganic & Medicinal Chemistry,2018(26):1776–1783. |
APA | Hao-Fei Yu.,Yi-Fen Wang.,Ya-Ping Liu.,Zi-Feng Yang.,Wan-Yi Huang.,...&Xu-Dong Zhao.(2018).Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells.Bioorganic & Medicinal Chemistry(26),1776–1783. |
MLA | Hao-Fei Yu,et al."Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells".Bioorganic & Medicinal Chemistry .26(2018):1776–1783. |
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