Further Evidence of an Association between NCAN rs1064395 and Bipolar Disorder | |
Lingyi Li2; Dong-Sheng Zhou1; Hong Chang2; Yan Bai3; Yuanfang He3; Fang Liu3; Xiao Xiao2; Xingxing Li1; Ming Li2; Lu Wang2 | |
刊名 | Molecular Neuropsychiatry
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2018 | |
期号 | 4页码:30–34 |
关键词 | Ncan Genome-wide Association Studies Bipolar Disorder Major Mood Disorders Meta-analysis |
DOI | 10.1159/000488590 |
英文摘要 | Genome-wide association studies suggest that rs1064395in the neurocan gene (NCAN) is a potential risk factor for bi-polar disorder (BPD), and further replication analyses inlarger independent samples are needed. We herein ana-lyzed rs1064395 in a Han Chinese sample of 1,146 BPD cas-es and 2,031 controls, followed by a meta-analysis of BPDsamples from worldwide populations including a total of15,318 cases and 91,990 controls. The meta-analysis foundthat rs1064395 showed a genome-wide significant associa-tion with BPD (p = 4.92 × 10 –9 , OR = 1.126 for the A allele),although it did not reach the significance level in the HanChinese sample (p = 0.415, OR = 1.070 for the A allele). Wealso examined the association between the single nucleo-tide polymorphisms and major depressive disorder (MDD)given the presumed genetic overlap between BPD andMDD, and rs1064395 was also associated with MDD (p =0.0068, OR = 1.067 for the A allele) in a meta-analysis of14,543 cases and 14,856 controls. Our data provide furtherevidence for the involvement of NCAN in the genetic sus-ceptibility to BPD and also implicate its broader role in ma-jor mood disorders. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://159.226.149.26:8080/handle/152453/12347] ![]() |
专题 | 昆明动物研究所_转化基因组 |
通讯作者 | Dong-Sheng Zhou |
作者单位 | 1.Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, PR China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, PR China 3.Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, PR China |
推荐引用方式 GB/T 7714 | Lingyi Li,Dong-Sheng Zhou,Hong Chang,et al. Further Evidence of an Association between NCAN rs1064395 and Bipolar Disorder[J]. Molecular Neuropsychiatry,2018(4):30–34. |
APA | Lingyi Li.,Dong-Sheng Zhou.,Hong Chang.,Yan Bai.,Yuanfang He.,...&Lu Wang.(2018).Further Evidence of an Association between NCAN rs1064395 and Bipolar Disorder.Molecular Neuropsychiatry(4),30–34. |
MLA | Lingyi Li,et al."Further Evidence of an Association between NCAN rs1064395 and Bipolar Disorder".Molecular Neuropsychiatry .4(2018):30–34. |
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