Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down- regulating Krüppel-like factor 5 transcription by Sp1 | |
Zhongmei Zhou2; Tianning Zou1; Runxiang Yang4; Ceshi Chen2; Hailin Zhang2; Xu Zhi3; Rong Liu2 | |
刊名 | SCIENTIFIC REPORTS
![]() |
2018 | |
期号 | 8页码:1138 |
DOI | 10.1038/s41598-018-19489-6 |
英文摘要 | As the most malignant breast cancer subtype, triple-negative breast cancer (TNBC) does not haveeffective targeted therapies clinically to date. As a selective Sp1 inhibitor, Mithramycin A (MIT) has beenreported to have anti-tumor activities in multiple cancers. However, the efficacy and the mechanismof MIT in breast cancer, especially TNBC, have not been studied. In this study, we demonstrated thatMIT suppressed breast cancer cell survival in a dosage-dependent manner. Interestingly, TNBC cellswere more sensitive to MIT than non-TNBC cells. MIT inhibited TNBC cell proliferation and promotedapoptosis in vitro in time- and dosage-dependent manners. MIT suppressed TNBC cell survival, at leastpartially, by transcriptionally down-regulating KLF5, an oncogenic transcription factor specificallyexpressed in basal TNBC. Finally, MIT suppressed TNBC cell growth in a xenograft mouse model. Takentogether, our findings suggested that MIT inhibits basal TNBC via the Sp1/KLF5 axis and that MIT maybe used for TNBC treatment. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://159.226.149.26:8080/handle/152453/12298] ![]() |
专题 | 昆明动物研究所_肿瘤生物学 |
通讯作者 | Ceshi Chen |
作者单位 | 1.Department of Breast Surgery, Yunnan Tumor Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650118, China. Rong Liu and Xu Zhi contributed equally to this work. Correspondence and requests for materials should be addressed to C.C. 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming, 650223, China. 3.Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China. 4.Department of Oncology, Yunnan Tumor Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650118, China. |
推荐引用方式 GB/T 7714 | Zhongmei Zhou,Tianning Zou,Runxiang Yang,et al. Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down- regulating Krüppel-like factor 5 transcription by Sp1[J]. SCIENTIFIC REPORTS,2018(8):1138. |
APA | Zhongmei Zhou.,Tianning Zou.,Runxiang Yang.,Ceshi Chen.,Hailin Zhang.,...&Rong Liu.(2018).Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down- regulating Krüppel-like factor 5 transcription by Sp1.SCIENTIFIC REPORTS(8),1138. |
MLA | Zhongmei Zhou,et al."Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down- regulating Krüppel-like factor 5 transcription by Sp1".SCIENTIFIC REPORTS .8(2018):1138. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论