Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine

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	Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine
	Su LY 2,5; Gao YG1,2,3,5; Xu L2,3; Ding YQ 4; Luo RC 2,5; Su JR 2,5; Liu QJ 2,5; Yang LX 2; yaoyg@mail.kiz.ac.cn
刊名	Autophagy
	2017
卷号	期号:页码:Epub ahead of print
关键词	Atg5 Atg7 Addiction Autophagy Dopaminergic Neuron Morphine
英文摘要	The molecular basis of chronic morphine exposure remains unknown. In this study, we hypothesized that macroautophagy/autophagy of dopaminergic neurons would mediate the alterations of neuronal dendritic morphology and behavioral responses induced by morphine. Chronic morphine exposure caused Atg5 (autophagy related 5)- and Atg7 (autophagy related 7)-dependent and dopaminergic neuron-specific autophagy resulting in decreased neuron dendritic spines and the onset of addictive behaviors. In cultured primary midbrain neurons, morphine treatment significantly reduced total dendritic length and complexity, and this effect could be reversed by knockdown of Atg5 or Atg7. Mice deficient for Atg5 or Atg7 specifically in the dopaminergic neurons were less sensitive to developing a morphine reward response, behavioral sensitization, analgesic tolerance and physical dependence compared to wild-type mice. Taken together, our findings suggested that the Atg5- and Atg7-dependent autophagy of dopaminergic neurons contributed to cellular and behavioral responses to morphine and may have implications for the future treatment of drug addiction.
语种	英语
资助机构	The study was done at Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), and was supported by the National Natural Science Foundation of China (31671050), the Strategic Priority Research Program (B) of CAS (XDB02020003) and the Bureau of Frontier Sciences and Education of CAS (QYZDJ-SSW-SMC005). ; The study was done at Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), and was supported by the National Natural Science Foundation of China (31671050), the Strategic Priority Research Program (B) of CAS (XDB02020003) and the Bureau of Frontier Sciences and Education of CAS (QYZDJ-SSW-SMC005). ; The study was done at Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), and was supported by the National Natural Science Foundation of China (31671050), the Strategic Priority Research Program (B) of CAS (XDB02020003) and the Bureau of Frontier Sciences and Education of CAS (QYZDJ-SSW-SMC005). ; The study was done at Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), and was supported by the National Natural Science Foundation of China (31671050), the Strategic Priority Research Program (B) of CAS (XDB02020003) and the Bureau of Frontier Sciences and Education of CAS (QYZDJ-SSW-SMC005).
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/11946]
专题	昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_重大疾病机理的遗传学昆明动物研究所_中国科学院昆明灵长类研究中心
通讯作者	yaoyg@mail.kiz.ac.cn
作者单位	1.Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 3.CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China 4.Key Laboratory of Arrhythmias, Department of Anatomy and Neurobiology, Tongji University School of Medicine Shanghai, Shanghai, China 5.Kunming College of Life Science,University of Chinese Academy of Sciences, Kunming, Yunnan, China
推荐引用方式 GB/T 7714	Su LY,Gao YG,Xu L,et al. Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine[J]. Autophagy,2017,():Epub ahead of print.
APA	Su LY.,Gao YG.,Xu L.,Ding YQ.,Luo RC.,...&yaoyg@mail.kiz.ac.cn.(2017).Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine.Autophagy,(),Epub ahead of print.
MLA	Su LY,et al."Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine".Autophagy .(2017):Epub ahead of print.