Comparative investigation of the binding characteristics of poly-L-lysine and chitosan on alginate hydrogel

doi:10.1016/j.ijbiomac.2015.12.008

	Comparative investigation of the binding characteristics of poly-L-lysine and chitosan on alginate hydrogel
	Ren, Ying 2,3; Xie, Hongguo 3; Liu, Xiaocen 2,3; Bao, Jie 1; Yu, Weiting 3; Ma, Xiaojun 3
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2016-03-01
卷号	84 页码:135-141
关键词	Alginate Chitosan Poly-l-lysine
ISSN号	0141-8130
DOI	10.1016/j.ijbiomac.2015.12.008
文献子类	Article
英文摘要	The binding properties of poly-L-lysine and chitosan to alginate have been evaluated quantitatively and compared. Poly-L-lysine bound to alginate hydrogel more rapidly than chitosan as poly-L-lysine has a smaller molar hydrodynamic volume. In addition, poly-L-lysine showed a much higher binding capacity (6.14:1) for alginate hydrogel beads than chitosan (2.71:1), and a little higher binding stoichiometry (0.58) to sodium alginate molecules in solution than chitosan (0.49). An exothermic heat of alginate-poly-L-lysine complexes formation of 2.02 kJ/mol was detected. For alginate-chitosan complexes, the binding enthalpy has been seen to be -3.49 kJ/mol. The stability of the polyelectrolyte complexes was related to their binding enthalpy. The alginate-poly-L-lysine complexes could be disintegrated and rebuilt. By contrast, chitosan was bound with alginate in a steady state. These results provide fundamental insights regarding the structure and property relationships of macromolecules, and will be helpful in designing and selecting appropriate polymers. (C) 2015 Published by Elsevier B.V.
WOS关键词	POLYELECTROLYTE MULTILAYERS ; DRUG-DELIVERY ; MICROCAPSULES ; COMPLEXATION ; POLYCATION ; MICROSCOPY ; STABILITY ; MICROGELS ; PEPTIDE ; GROWTH
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000369456800018
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/171388]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Xie, Hongguo; Yu, Weiting
作者单位	1.E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, 457 Zhongshan Rd, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Ren, Ying,Xie, Hongguo,Liu, Xiaocen,et al. Comparative investigation of the binding characteristics of poly-L-lysine and chitosan on alginate hydrogel[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2016,84:135-141.
APA	Ren, Ying,Xie, Hongguo,Liu, Xiaocen,Bao, Jie,Yu, Weiting,&Ma, Xiaojun.(2016).Comparative investigation of the binding characteristics of poly-L-lysine and chitosan on alginate hydrogel.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,84,135-141.
MLA	Ren, Ying,et al."Comparative investigation of the binding characteristics of poly-L-lysine and chitosan on alginate hydrogel".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 84(2016):135-141.