Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer

doi:10.1038/srep20984

	Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer
	Sun, Yinghao 1; Xu, Guowang 2; Li, Jia 2; Ren, Shancheng 1; Piao, Hai-long 2; Wang, Fubo 1; Yin, Peiyuan 2; Xu, Chuanliang 1; Lu, Xin 2; Ye, Guozhu 2
刊名	SCIENTIFIC REPORTS
	2016-02-11
卷号	6
ISSN号	2045-2322
DOI	10.1038/srep20984
文献子类	Article
英文摘要	In-depth delineation of lipid metabolism in prostate cancer (PCa) is significant to open new insights into prostate tumorigenesis and progression, and provide potential biomarkers with greater accuracy for improved diagnosis. Here, we performed lipidomics and transcriptomics in paired prostate cancer tumor (PCT) and adjacent nontumor (ANT) tissues, followed by external validation of biomarker candidates. We identified major dysregulated pathways involving lipogenesis, lipid uptake and phospholipids remodeling, correlated with widespread lipid accumulation and lipid compositional reprogramming in PCa. Specifically, cholesteryl esters (CEs) were most prominently accumulated in PCa, and significantly associated with cancer progression and metastasis. We showed that overexpressed scavenger receptor class B type I (SR-BI) may contribute to CEs accumulation. In discovery set, CEs robustly differentiated PCa from nontumor (area under curve (AUC) of receiver operating characteristics (ROC), 0.90-0.94). In validation set, CEs potently distinguished PCa and non-malignance (AUC, 0.84-0.91), and discriminated PCa and benign prostatic hyperplasia (BPH) (AUC, 0.90-0.96), superior to serum prostate-specific antigen (PSA) (AUC = 0.83). Cholesteryl oleate showed highest AUCs in distinguishing PCa from non-malignance or BPH (AUC = 0.91 and 0.96). Collectively, our results unravel the major lipid metabolic aberrations in PCa and imply the potential role of CEs, particularly, cholesteryl oleate, as molecular biomarker for PCa detection.
WOS关键词	INTRATUMORAL ANDROGENS ; PROGRESSION ; PROLIFERATION ; GROWTH ; CELLS ; PHOSPHOLIPIDS ; ACCUMULATION ; METABOLOMICS ; INFORMATION ; STATISTICS
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000369923500001
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/171218]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Sun, Yinghao; Xu, Guowang
作者单位	1.Second Mil Med Univ, Shanghai Changhai Hosp, Dept Urol, Shanghai, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Sun, Yinghao,Xu, Guowang,Li, Jia,et al. Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer[J]. SCIENTIFIC REPORTS,2016,6.
APA	Sun, Yinghao.,Xu, Guowang.,Li, Jia.,Ren, Shancheng.,Piao, Hai-long.,...&Zhao, Xinjie.(2016).Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer.SCIENTIFIC REPORTS,6.
MLA	Sun, Yinghao,et al."Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer".SCIENTIFIC REPORTS 6(2016).