Development and application of bond cleavage reactions in bioorthogonal chemistry

doi:10.1038/NCHEMBIO.2024

	Development and application of bond cleavage reactions in bioorthogonal chemistry
	Li, Jie 1; Chen, Peng R.1,2
刊名	NATURE CHEMICAL BIOLOGY
	2016-03-01
卷号	12 期号:3 页码:129-137
ISSN号	1552-4450
DOI	10.1038/NCHEMBIO.2024
文献子类	Article
英文摘要	Bioorthogonal chemical reactions are a thriving area of chemical research in recent years as an unprecedented technique to dissect native biological processes through chemistry-enabled strategies. However, current concepts of bioorthogonal chemistry have largely centered on 'bond formation' reactions between two mutually reactive bioorthogonal handles. Recently, in a reverse strategy, a collection of 'bond cleavage' reactions has emerged with excellent biocompatibility. These reactions have expanded our bioorthogonal chemistry repertoire, enabling an array of exciting new biological applications that range from the chemically controlled spatial and temporal activation of intracellular proteins and small-molecule drugs to the direct manipulation of intact cells under physiological conditions. Here we highlight the development and applications of these bioorthogonal cleavage reactions. Furthermore, we lay out challenges and propose future directions along this appealing avenue of research.
WOS关键词	LIVING CELLS ; CLICK CHEMISTRY ; PROTECTING GROUPS ; GENETIC-CODE ; TETRAZINE LIGATION ; FLUORESCENT-PROBE ; PROTEIN FUNCTION ; SMALL MOLECULES ; VISIBLE-LIGHT ; HUMAN GENOME
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000371377000003
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/171036]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Chen, Peng R.
作者单位	1.Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Synthet & Funct Biomol Ctr,Minist Educ, Beijing Natl Lab Mol Sci,Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Jie,Chen, Peng R.. Development and application of bond cleavage reactions in bioorthogonal chemistry[J]. NATURE CHEMICAL BIOLOGY,2016,12(3):129-137.
APA	Li, Jie,&Chen, Peng R..(2016).Development and application of bond cleavage reactions in bioorthogonal chemistry.NATURE CHEMICAL BIOLOGY,12(3),129-137.
MLA	Li, Jie,et al."Development and application of bond cleavage reactions in bioorthogonal chemistry".NATURE CHEMICAL BIOLOGY 12.3(2016):129-137.