Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry

doi:10.1021/acs.jproteome.6b00022

	Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry
	Luo, Ping 1; Yu, Haoyong 2; Zhao, Xinjie 1; Bao, Yuqian 2; Hong, Christopher S.3; Zhang, Pin 4; Tu, Yinfang 2; Yin, Peiyuan 1; Gao, Peng 1; Wei, Li 2
刊名	JOURNAL OF PROTEOME RESEARCH
	2016-04-01
卷号	15 期号:4 页码:1288-1299
关键词	Metabolomics Metabolic Profiling Roux-en-y Gastric Bypass Rygb Diabetes
ISSN号	1535-3893
DOI	10.1021/acs.jproteome.6b00022
文献子类	Article
英文摘要	Roux-en-Y gastric bypass (RYGB) is one of the most effective treatments for long-term weight loss and diabetes remission; however, the mechanisms underlying these changes are not clearly understood. In this study, the serum metabolic profiles of 23 remission and 12 nonremission patients with type 2 diabetes mellitus (T2DM) were measured at baseline, 6- and 12-months after RYGB. A metabolomics analysis was performed based on ultra-performance liquid chromatography mass spectrometry. Clinical improvements in insulin sensitivity, energy metabolism, and inflammation were related to metabolic alterations of free fatty acids (FFAs), acylcarnitines, amino acids, bile acids, and lipids species. Differential metabolic profiles were observed between the two T2DM subgroups, and patients with severity fat accumulation and oxidation stress may be more suitable for RYGB. Baseline levels of tryptophan, bilirubin, and indoxyl sulfate measured prior to surgery as well as levels of FFA 16:0, FFA 18:3, FFA 17:2, and hippuric acid measured at 6 months after surgery best predicted the suitability and efficacy of RYGB for patients with T2DM. These metabolites represent potential biomarkers that may be clinically helpful in individualized treatment for T2DM patients by RYGB.
WOS关键词	STEAROYL-COA DESATURASE ; CHAIN AMINO-ACIDS ; INSULIN-RESISTANCE ; BARIATRIC SURGERY ; SKELETAL-MUSCLE ; SERUM METABOLOMICS ; BETA-OXIDATION ; OBESE-PATIENTS ; BILE-ACIDS ; INFLAMMATION
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000373519900018
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/170684]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Jia, Weiping; Xu, Guowang
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China 2.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Key Lab Diabet Mellitus,Shanghai Diabet, Dept Endocrinol & Metab,Shanghai Clin Ctr Diabet, Yishan Rd 600, Shanghai 200233, Peoples R China 3.NINDS, NIH, Surg Neurol Branch, Bethesda, MD 20892 USA 4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Gen Surg, Yishan Rd, Shanghai 200233, Peoples R China
推荐引用方式 GB/T 7714	Luo, Ping,Yu, Haoyong,Zhao, Xinjie,et al. Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry[J]. JOURNAL OF PROTEOME RESEARCH,2016,15(4):1288-1299.
APA	Luo, Ping.,Yu, Haoyong.,Zhao, Xinjie.,Bao, Yuqian.,Hong, Christopher S..,...&Xu, Guowang.(2016).Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry.JOURNAL OF PROTEOME RESEARCH,15(4),1288-1299.
MLA	Luo, Ping,et al."Metabolomics Study of Roux-en-Y Gastric Bypass Surgery (RYGB) to Treat Type 2 Diabetes Patients Based on Ultraperformance Liquid Chromatography-Mass Spectrometry".JOURNAL OF PROTEOME RESEARCH 15.4(2016):1288-1299.