Response Characteristics of Bisphenols on a Metal-Organic Framework-Based Tyrosinase Nanosensor

doi:10.1021/acsami.6b05008

	Response Characteristics of Bisphenols on a Metal-Organic Framework-Based Tyrosinase Nanosensor
	Lu, Xianbo 2; Wang, Xue 2,3; Wu, Lidong 1; Wu, Lingxia 2; Dhanjai 2; Fu, Lei 2; Gao, Yuan 2; Chen, Jiping 2
刊名	ACS APPLIED MATERIALS & INTERFACES
	2016-06-29
卷号	8 期号:25 页码:16533-16539
关键词	Bisphenols Heavy Metal Ions Electrochemical Response Mechanism Metal-organic Frameworks Tyrosinase Biosensor
ISSN号	1944-8244
DOI	10.1021/acsami.6b05008
文献子类	Article
英文摘要	Bisphenols (BPs), which have more than ten kinds of structural analogues, are emerging as the most important endocrine disrupting chemicals that adversely affect human health and aquatic life. A tyrosinase nanosensor based on metal-organic frameworks (MOFs) and chitosan was developed to investigate the electrochemical response characteristics and mechanisms of nine kinds of BPs for the first time. The developed tyrosinase nanosensor showed a sensitive response to bisphenol A, bisphenol F, bisphenol E, bisphenol B, and bisphenol Z, and the responsive sensitivities were highly dependent on their respective log K-ow values. However, the nanosensor showed no response to bisphenol S (BPS), bisphenol AP (BPAP), bisphenol AF (BPAF), or tetrabromobisphenol A, although BPS, BPAP, and BPAF have structures similar to those of the responsive BPs. The obtained results reveal that the electrochemical response of different BPs is affected not only by the molecular structure, especially the available ortho positions of phenolic hydroxyl groups, but also by the substituent group properties (electron acceptor or electron donor) on the bisphenol framework. The electronic cloud distribution of the phenolic hydroxyl groups, which is affected by the substituent group, determines whether the available ortho positions of phenolic hydroxyl groups can be oxidized by the tyrosinase biosensor. These response mechanisms are very significant as they can be used for predicting the response characteristics of many BPs and their various derivatives and metabolites on biosensors. The unexpected anti-interference ability of the biosensor to nine heavy metal ions was also discovered and discussed. The MOF-chitosan nanocomposite proves to be a promising sensing platform for the construction of diverse biosensors for selective detection of targets even in the presence of a high concentration of heavy metal ions.
WOS关键词	ELECTROCHEMICAL BIOSENSOR ; AMPEROMETRIC BIOSENSOR ; RAPID DETECTION ; DERIVATIVES ; ELECTRODE ; CHITOSAN ; TOXICITY ; PROTEINS ; REMOVAL ; HEALTH
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000378984800076
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/170452]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Lu, Xianbo; Chen, Jiping
作者单位	1.Chinese Acad Fishery Sci, Beijing 100141, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.Dalian Univ Technol, Sch Food & Environm, Panjin 124221, Peoples R China
推荐引用方式 GB/T 7714	Lu, Xianbo,Wang, Xue,Wu, Lidong,et al. Response Characteristics of Bisphenols on a Metal-Organic Framework-Based Tyrosinase Nanosensor[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(25):16533-16539.
APA	Lu, Xianbo.,Wang, Xue.,Wu, Lidong.,Wu, Lingxia.,Dhanjai.,...&Chen, Jiping.(2016).Response Characteristics of Bisphenols on a Metal-Organic Framework-Based Tyrosinase Nanosensor.ACS APPLIED MATERIALS & INTERFACES,8(25),16533-16539.
MLA	Lu, Xianbo,et al."Response Characteristics of Bisphenols on a Metal-Organic Framework-Based Tyrosinase Nanosensor".ACS APPLIED MATERIALS & INTERFACES 8.25(2016):16533-16539.