Synthesis of Chiral Fluorinated Propargylamines via Chemoselective Biomimetic Hydrogenation

doi:10.1021/acs.orglett.6b02283

	Synthesis of Chiral Fluorinated Propargylamines via Chemoselective Biomimetic Hydrogenation
	Chen, Zhang-Pei 1; Zhou, Yong-Gui 1,2; Chen, Mu-Wang 1; Wu, Bo 1; Shi, Lei 1
刊名	ORGANIC LETTERS
	2016-09-16
卷号	18 期号:18 页码:4650-4653
ISSN号	1523-7060
DOI	10.1021/acs.orglett.6b02283
文献子类	Article
英文摘要	A highly enantioselective synthesis of chiral fluorinated propargylamines was developed through phosphoric acid and ruthenium-catalyzed chemoselective biomimetic hydrogenation of the carbon nitrogen double bond of fluorinated alkynyl ketimines in the presence of a carbon carbon triple bond. This reaction features high chemoselectivity and slow background reaction. In addition, selective transformations of the chiral fluorinated propargylamines were also reported.
WOS关键词	ASYMMETRIC TRANSFER HYDROGENATION ; CATALYZED TRANSFER HYDROGENATION ; ORGANOCATALYTIC TRANSFER HYDROGENATION ; MANNICH-TYPE REACTIONS ; IN-SITU REGENERATION ; HANTZSCH ESTERS ; BRONSTED ACID ; ENANTIOSELECTIVE SYNTHESIS ; NAD(P)H MODEL ; REDUCTIVE AMINATION
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000383640600052
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/170182]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Zhou, Yong-Gui
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Chen, Zhang-Pei,Zhou, Yong-Gui,Chen, Mu-Wang,et al. Synthesis of Chiral Fluorinated Propargylamines via Chemoselective Biomimetic Hydrogenation[J]. ORGANIC LETTERS,2016,18(18):4650-4653.
APA	Chen, Zhang-Pei,Zhou, Yong-Gui,Chen, Mu-Wang,Wu, Bo,&Shi, Lei.(2016).Synthesis of Chiral Fluorinated Propargylamines via Chemoselective Biomimetic Hydrogenation.ORGANIC LETTERS,18(18),4650-4653.
MLA	Chen, Zhang-Pei,et al."Synthesis of Chiral Fluorinated Propargylamines via Chemoselective Biomimetic Hydrogenation".ORGANIC LETTERS 18.18(2016):4650-4653.