Controlling Gel Structure to Modulate Cell Adhesion and Spreading on the Surface of Microcapsules

doi:10.1021/acsami.6b05778

	Controlling Gel Structure to Modulate Cell Adhesion and Spreading on the Surface of Microcapsules
	Zheng, Huizhen 1,2; Gao, Meng 1,2; Ren, Ying 1,2; Lou, Ruyun 1,2; Xie, Hongguo 1; Yu, Weiting 1; Liu, Xiudong 3; Ma, Xiaojun 1
刊名	ACS APPLIED MATERIALS & INTERFACES
	2016-08-03
卷号	8 期号:30 页码:19333-19342
关键词	Alginate-chitosan Microcapsule Gel Structure Protonated Amino Cell Adhesion And Spreading Surface Property
ISSN号	1944-8244
DOI	10.1021/acsami.6b05778
文献子类	Article
英文摘要	The surface properties of implanted materials or devices play critical roles in modulating cell behavior. However, the surface properties usually affect cell behaviors synergetically so that it is, still difficult to separately investigate the influence of a single property on cell behavior in practical applications. In this study, alginate chitosan (AC) microcapsules with a dense or loose gel structure were fabricated to understand the effect of gel structure on cell behavior. Cells preferentially adhered and spread on the loose gel structure microcapsules-rather than on the dense ones. The two types of microcapsules exhibited nearly identical surface positive charges, roughness, stiffness, and hydrophilicity; thus, the result suggested that the gel structure was the principal factor affecting cell behavior. X-ray photoelectron spectroscopy analyses demonstrated that the overall percentage Of positively charged amino groups was similar on both microcapsules. The different gel structures led to different states and distributions of the, positively charged amino groups of chitosan, so we conclude that the loose gel structure facilitated greater cell adhesion and spreading mainly because more protonated amino groups remained unbound and exposed on the surface of these microcapsules.
WOS关键词	ALGINATE-BASED MICROCAPSULES ; PANCREATIC-ISLETS ; CHITOSAN ; BIOCOMPATIBILITY ; ENCAPSULATION ; MICROSPHERES ; TISSUE
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000380968300018
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/170086]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Yu, Weiting; Liu, Xiudong
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, 457 Zhongshan Rd, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Dalian Univ, Coll Environm & Chem Engn, Dalian Econ Technol Dev Zone, Dalian 116622, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Huizhen,Gao, Meng,Ren, Ying,et al. Controlling Gel Structure to Modulate Cell Adhesion and Spreading on the Surface of Microcapsules[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(30):19333-19342.
APA	Zheng, Huizhen.,Gao, Meng.,Ren, Ying.,Lou, Ruyun.,Xie, Hongguo.,...&Ma, Xiaojun.(2016).Controlling Gel Structure to Modulate Cell Adhesion and Spreading on the Surface of Microcapsules.ACS APPLIED MATERIALS & INTERFACES,8(30),19333-19342.
MLA	Zheng, Huizhen,et al."Controlling Gel Structure to Modulate Cell Adhesion and Spreading on the Surface of Microcapsules".ACS APPLIED MATERIALS & INTERFACES 8.30(2016):19333-19342.