Mercaptophenylboronic acid-capped Mn-doped ZnS quantum dots for highly selective and sensitive fluorescence detection of glycoproteins

doi:10.1016/j.snb.2016.11.121

	Mercaptophenylboronic acid-capped Mn-doped ZnS quantum dots for highly selective and sensitive fluorescence detection of glycoproteins
	He, Xiwen 1; Zhang, Yukui 1,3; Chang, Lifang 1; Chen, Langxing 1,2
刊名	SENSORS AND ACTUATORS B-CHEMICAL
	2017-05-01
卷号	243 页码:72-77
关键词	Mn-doped Zns Quantum Dots Fluorescent Enhanced Sensor Boronate-affinity Glycoproteins Transferrin
ISSN号	0925-4005
DOI	10.1016/j.snb.2016.11.121
文献子类	Article
英文摘要	In this work, a novel fluorescent turn-on sensor for the detection of glycoproteins based upon measuring the fluorescence enhancement of mercaptophenylboronic acid-capped Mn-doped ZnS quantum dots (QDs@MBA) was developed. Transferrin (TRF), as one of glycoproteins, was introduced to evaluate characteristics of the fluorescent probe. The TRF bound onto MBA via boronate affinity interaction can efficiently enhance the fluorescence of QDs@MBA through a blocked electron transfer process from the QDs to the boronic acid moieties. Approximately 2.6-fold fluorescence enhancement of Qps@MBA at 610 nm can be observed in presence of 10.0 mu M TRF within 10 min. The QDs@MBA can sensitively detect down to 5.69 x 10(-9) M TRF in aqueous solution and the linear range is 0.10-10.0 mu M. Moreover, QPs@MBA was also applied to detect TRF in serum sample, and the recovery can achieve 87.9%-96.5%. This sensor shows a great potential for detecting glyproteins present in the complex biological or biomedical samples. (C) 2016 Elsevier B.V. All rights reserved.
WOS关键词	ROOM-TEMPERATURE PHOSPHORESCENCE ; ENERGY-TRANSFER ; PROTEIN GLYCOSYLATION ; BORONIC ACIDS ; IN-VITRO ; SENSOR ; NANOPARTICLES ; NANOCRYSTALS ; EMISSION ; AFFINITY
WOS研究方向	Chemistry ; Electrochemistry ; Instruments & Instrumentation
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000395969100011
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/169316]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Chen, Langxing
作者单位	1.Nankai Univ, Coll Chem, Res Ctr Analyt Sci, Tianjin Key Lab Biosensing & Mol Recognit,State K, Tianjin 300071, Peoples R China 2.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	He, Xiwen,Zhang, Yukui,Chang, Lifang,et al. Mercaptophenylboronic acid-capped Mn-doped ZnS quantum dots for highly selective and sensitive fluorescence detection of glycoproteins[J]. SENSORS AND ACTUATORS B-CHEMICAL,2017,243:72-77.
APA	He, Xiwen,Zhang, Yukui,Chang, Lifang,&Chen, Langxing.(2017).Mercaptophenylboronic acid-capped Mn-doped ZnS quantum dots for highly selective and sensitive fluorescence detection of glycoproteins.SENSORS AND ACTUATORS B-CHEMICAL,243,72-77.
MLA	He, Xiwen,et al."Mercaptophenylboronic acid-capped Mn-doped ZnS quantum dots for highly selective and sensitive fluorescence detection of glycoproteins".SENSORS AND ACTUATORS B-CHEMICAL 243(2017):72-77.