Conversion of Aromatic Amino into Trifluoromethyl Groups through a Sandmeyer-Type Transformation

doi:10.1055/s-0033-1338659

	Conversion of Aromatic Amino into Trifluoromethyl Groups through a Sandmeyer-Type Transformation
	Zhang, Yan; Wang, Xi; Xu, Yan; Zhou, Yujing; Wang, Jianbo
刊名	SYNTHESIS-STUTTGART
	2014-08-01
卷号	46 期号:16 页码:2143-2148
关键词	Trifluoromethylation Aromatic Amines Diazonium Salts Silver Sandmeyer Reaction
ISSN号	0039-7881
DOI	10.1055/s-0033-1338659
文献子类	Article
英文摘要	A novel strategy for aromatic trifluoromethylation by converting amino into trifluoromethyl groups via a Sandmeyer-type reaction is reported. The transformation involves diazotization of the aromatic amines with tert-butyl nitrite and hydrochloric acid to form aryldiazonium chlorides, followed by trifluoromethylation with trifluoromethylsilver at low temperature. Various readily available aromatic amines are smoothly converted under mild conditions.
WOS关键词	PALLADIUM-CATALYZED TRIFLUOROMETHYLATION ; SILVER-MEDIATED TRIFLUOROMETHYLATION ; BORONIC ACIDS ; ARYLBORONIC ACIDS ; SYNTHETIC METHODS ; DIAZONIUM SALTS ; ALKYL NITRITES ; ARYL STANNANES ; ARENES ; PERFLUOROALKYLATION
WOS研究方向	Chemistry
语种	英语
出版者	GEORG THIEME VERLAG KG
WOS记录号	WOS:000340875300004
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/167358]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Wang, Jianbo
作者单位	Peking Univ, Coll Chem, Key Lab Bioorgan Chem & Mol Engn, Beijing Natl Lab Mol Sci BNLMS,Minist Educ, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yan,Wang, Xi,Xu, Yan,et al. Conversion of Aromatic Amino into Trifluoromethyl Groups through a Sandmeyer-Type Transformation[J]. SYNTHESIS-STUTTGART,2014,46(16):2143-2148.
APA	Zhang, Yan,Wang, Xi,Xu, Yan,Zhou, Yujing,&Wang, Jianbo.(2014).Conversion of Aromatic Amino into Trifluoromethyl Groups through a Sandmeyer-Type Transformation.SYNTHESIS-STUTTGART,46(16),2143-2148.
MLA	Zhang, Yan,et al."Conversion of Aromatic Amino into Trifluoromethyl Groups through a Sandmeyer-Type Transformation".SYNTHESIS-STUTTGART 46.16(2014):2143-2148.