Cleavage of the C= N Bond in Carbodiimides via Release of High Ring Strain: A New Strategy for the Selective Synthesis of 2-Aminoaryl Alkynyl Imines

doi:10.1002/chem.201304701

	Cleavage of the C= N Bond in Carbodiimides via Release of High Ring Strain: A New Strategy for the Selective Synthesis of 2-Aminoaryl Alkynyl Imines
	Zhou, Yi 2; Chi, Yue 2; Zhao, Fei 2; Zhang, Wen-Xiong 1,2; Xi, Zhenfeng 2
刊名	CHEMISTRY-A EUROPEAN JOURNAL
	2014-02-24
卷号	20 期号:9 页码:2463-2468
关键词	Alkynes Benzynes Cn Activation Carbodiimides Multicomponent Reactions
ISSN号	0947-6539
DOI	10.1002/chem.201304701
文献子类	Article
英文摘要	A novel pattern of the cleavage and reorganization of CN bond in the multicomponent reaction (MCR) of terminal alkynes or haloalkynes, carbodiimides, and benzynes is achieved for the first time to construct efficiently 2-aminoaryl alkynyl imines. The selective formation and ring-opening of the azetine intermediate with the high ring strain is essential for this reaction. Further transformation of 2-aminoaryl alkynyl imines via the Cu-catalyzed cycloisomerization is explored to provide steroselectively the bi-, tri-, and tetracyclic fused pyrrolines.
WOS关键词	EARTH-METAL COMPLEXES ; MULTICOMPONENT COUPLING REACTIONS ; TERMINAL ALKYNES ; CARBON-CARBON ; ORGANOACTINIDE COMPLEXES ; METATHESIS REACTIONS ; GUANIDINATE LIGANDS ; CATALYTIC ADDITION ; ORGANIC-SYNTHESIS ; IMIDO COMPLEXES
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000331729700012
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/167308]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Zhang, Wen-Xiong
作者单位	1.Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China 2.Peking Univ, Coll Chem, Key Lab Bioorgan Chem & Mol Engn, BNLMS,Minist Educ, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Yi,Chi, Yue,Zhao, Fei,et al. Cleavage of the C= N Bond in Carbodiimides via Release of High Ring Strain: A New Strategy for the Selective Synthesis of 2-Aminoaryl Alkynyl Imines[J]. CHEMISTRY-A EUROPEAN JOURNAL,2014,20(9):2463-2468.
APA	Zhou, Yi,Chi, Yue,Zhao, Fei,Zhang, Wen-Xiong,&Xi, Zhenfeng.(2014).Cleavage of the C= N Bond in Carbodiimides via Release of High Ring Strain: A New Strategy for the Selective Synthesis of 2-Aminoaryl Alkynyl Imines.CHEMISTRY-A EUROPEAN JOURNAL,20(9),2463-2468.
MLA	Zhou, Yi,et al."Cleavage of the C= N Bond in Carbodiimides via Release of High Ring Strain: A New Strategy for the Selective Synthesis of 2-Aminoaryl Alkynyl Imines".CHEMISTRY-A EUROPEAN JOURNAL 20.9(2014):2463-2468.