Copper-catalyzed propargylic [3+3] cycloaddition with 1H-pyrazol-5(4H)-ones: enantioselective access to optically active dihydropyrano[2,3-c]pyrazoles

doi:10.1039/c8cc05706k

	Copper-catalyzed propargylic [3+3] cycloaddition with 1H-pyrazol-5(4H)-ones: enantioselective access to optically active dihydropyrano[2,3-c]pyrazoles
	Li, Ling 1,2; Hu, Xiang-Ping 1; Liu, Zhen-Ting 1,2
刊名	CHEMICAL COMMUNICATIONS
	2018-11-04
卷号	54 期号:85 页码:12033-12036
ISSN号	1359-7345
DOI	10.1039/c8cc05706k
通讯作者	Hu, Xiang-Ping(xiangping@dicp.ac.cn)
英文摘要	A copper-catalyzed asymmetric propargylic [3+3] cycloaddition with 1H-pyrazol-5(4H)-ones as C,O-bisnucleophiles through the desilylation-activated strategy has been developed. With the catalysis of Cu(OAc)(2)H2O in combination with a chiral tridentate P,N,N-ligand, the reaction displayed a broad substrate scope, and thus provided a variety of chiral dihydropyrano[2,3-c]pyrazoles in high yields and with excellent enantioselectivities (up to 96% ee).
WOS关键词	SUBSTITUTION-REACTIONS ; SYNERGISTIC CATALYSIS ; BETA-KETOESTERS ; ESTERS ; AMINATION ; INDOLES ; DERIVATIVES ; ACETATES ; AMINES ; ALKYLATION
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000447980500011
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/166866]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Hu, Xiang-Ping
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Ling,Hu, Xiang-Ping,Liu, Zhen-Ting. Copper-catalyzed propargylic [3+3] cycloaddition with 1H-pyrazol-5(4H)-ones: enantioselective access to optically active dihydropyrano[2,3-c]pyrazoles[J]. CHEMICAL COMMUNICATIONS,2018,54(85):12033-12036.
APA	Li, Ling,Hu, Xiang-Ping,&Liu, Zhen-Ting.(2018).Copper-catalyzed propargylic [3+3] cycloaddition with 1H-pyrazol-5(4H)-ones: enantioselective access to optically active dihydropyrano[2,3-c]pyrazoles.CHEMICAL COMMUNICATIONS,54(85),12033-12036.
MLA	Li, Ling,et al."Copper-catalyzed propargylic [3+3] cycloaddition with 1H-pyrazol-5(4H)-ones: enantioselective access to optically active dihydropyrano[2,3-c]pyrazoles".CHEMICAL COMMUNICATIONS 54.85(2018):12033-12036.