Synthesis of Benzofuran-fused 1,4-Dihydropyridines via Bifunctional Squaramide-catalyzed Formal [4+2] Cycloaddition of Azadienes with Malononitrile

doi:10.1002/cjoc.201800330

	Synthesis of Benzofuran-fused 1,4-Dihydropyridines via Bifunctional Squaramide-catalyzed Formal [4+2] Cycloaddition of Azadienes with Malononitrile
	Gu, Zheng 2; Wu, Bo 1; Jiang, Guo-Fang 2; Zhou, Yong-Gui 1
刊名	CHINESE JOURNAL OF CHEMISTRY
	2018-12-01
卷号	36 期号:12 页码:1130-1134
关键词	1,4-dihydropyridines cycloaddition azadienes tandem reactions organocatalysis asymmetric synthesis
ISSN号	1001-604X
DOI	10.1002/cjoc.201800330
通讯作者	Zhou, Yong-Gui(ygzhou@dicp.ac.cn)
英文摘要	An efficient bifunctional squaramide-catalyzed Michael addition/cyclization of azadienes with malononitrile has been successfully developed, providing a facile access to chiral benzofuran-fused 1,4-dihydropyridines with excellent yields, wide substrate scope and up to 99% ee. Additionally, this formal [4+2] cycloaddition can be performed in gram scale without noticeable loss of yield and enantioselectivity.
资助项目	National Natural Science Foundation of China[21532006] ; Dalian Bureau of Science and Technology[2016RD07] ; Dalian Institute of Chemical Physics[ZZBS201602]
WOS关键词	ORTHO-QUINONE METHIDES ; ENANTIOSELECTIVE CONJUGATE ADDITIONS ; ORGANOCATALYTIC ASYMMETRIC-SYNTHESIS ; DIELS-ALDER REACTION ; K+ CHANNEL OPENER ; IN-SITU ; ALPHA,BETA-UNSATURATED IMIDES ; KINETIC RESOLUTION ; MANNICH REACTION ; TRANSFER HYDROGENATION
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000450017200002
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/166690]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Zhou, Yong-Gui
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Liaoning, Peoples R China 2.Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Gu, Zheng,Wu, Bo,Jiang, Guo-Fang,et al. Synthesis of Benzofuran-fused 1,4-Dihydropyridines via Bifunctional Squaramide-catalyzed Formal [4+2] Cycloaddition of Azadienes with Malononitrile[J]. CHINESE JOURNAL OF CHEMISTRY,2018,36(12):1130-1134.
APA	Gu, Zheng,Wu, Bo,Jiang, Guo-Fang,&Zhou, Yong-Gui.(2018).Synthesis of Benzofuran-fused 1,4-Dihydropyridines via Bifunctional Squaramide-catalyzed Formal [4+2] Cycloaddition of Azadienes with Malononitrile.CHINESE JOURNAL OF CHEMISTRY,36(12),1130-1134.
MLA	Gu, Zheng,et al."Synthesis of Benzofuran-fused 1,4-Dihydropyridines via Bifunctional Squaramide-catalyzed Formal [4+2] Cycloaddition of Azadienes with Malononitrile".CHINESE JOURNAL OF CHEMISTRY 36.12(2018):1130-1134.