Single-Cell Proteomics for Cancer Immunotherapy

doi:10.1016/bs.acr.2018.04.006

	Single-Cell Proteomics for Cancer Immunotherapy
	Li, Linmei 3; Yan, Shiqiang 3; Lin, Bingcheng 3; Shi, Qihui 1,2,4; Lu, Yao 3
刊名	CANCER NANOTECHNOLOGY
	2018
卷号	139 页码:185-207
ISSN号	0065-230X
DOI	10.1016/bs.acr.2018.04.006
通讯作者	Shi, Qihui(qihuishi@fudan.edu.cn) ; Lu, Yao(luyao@dicp.ac.cn)
英文摘要	Cancer immunotherapy fights against cancer by modulating the immune response and is delivering encouraging results in clinical treatments. However, it is challenging to achieve durable response in all cancer patients during treatment due to the diversity and dynamic nature of immune system as well as inter-and intratumor heterogeneity. A comprehensive assessment of system immunity and tumor microenvironment is crucial for effective and safe cancer therapy, which can potentially be resolved by single-cell proteomic analysis. Single-cell proteomic technologies enable system-wide profiling of protein levels in a number of single cells within the immune system and tumor microenvironment, and thereby provide direct assessment of the functional state of the immune cells and tumor-immune interaction that could be used to evaluate efficacy of immunotherapy and to improve clinical outcome. In this chapter, we summarized current single-cell proteomic technologies and their applications in cancer immunotherapy.
WOS关键词	MULTIPLEXED PROTEIN-ANALYSIS ; FLOW-CYTOMETRY ; MASS CYTOMETRY ; T-CELLS ; CYTOKINE SECRETION ; RESPONSES ; ANTIBODY ; REVEALS ; HETEROGENEITY ; LYMPHOMA
WOS研究方向	Oncology
语种	英语
出版者	ELSEVIER ACADEMIC PRESS INC
WOS记录号	WOS:000453659500009
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/166412]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Shi, Qihui; Lu, Yao
作者单位	1.Fudan Univ, Zhongshan Hosp, Minhang Branch, Shanghai, Peoples R China 2.Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China 4.Fudan Univ, Minhang Hosp, Inst Fudan Minhang Acad Hlth Syst, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Li, Linmei,Yan, Shiqiang,Lin, Bingcheng,et al. Single-Cell Proteomics for Cancer Immunotherapy[J]. CANCER NANOTECHNOLOGY,2018,139:185-207.
APA	Li, Linmei,Yan, Shiqiang,Lin, Bingcheng,Shi, Qihui,&Lu, Yao.(2018).Single-Cell Proteomics for Cancer Immunotherapy.CANCER NANOTECHNOLOGY,139,185-207.
MLA	Li, Linmei,et al."Single-Cell Proteomics for Cancer Immunotherapy".CANCER NANOTECHNOLOGY 139(2018):185-207.