Gold Nanoshells with Verbascoside Induce the Apoptosis of Drug-Resistant Leukemia Cells Through Caspases Pathway and Inhibit Tumor Growth

	Gold Nanoshells with Verbascoside Induce the Apoptosis of Drug-Resistant Leukemia Cells Through Caspases Pathway and Inhibit Tumor Growth
	Ma, Zhinan ; Zhao, Xiaohui ; Jiang, Caiyun ; Yu, Jun ; Wu, Jiangping ; Zeng, Xin
刊名	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
	2016-07-01
英文摘要	In the present work, a new system of drug delivery to enhance the chemotherapy efficiency for cancer was established. Novel core-shell structures were presented here, which were consisted of poly (N-isopropyl acrylamide) (PNIPAM) microspheres as cores and gold as shells. Next, the chemotherapeutic agent Verbascoside (VB) was combined with PNIPAM/gold nanoshells (GNSs) structures (PMS) for inducing apoptosis in drug resistant leukemia cells (K562/A02; KA). The exploration on xenografted tumors in KA nude mice indicated that anticancer drug loaded on PNIPAM/GNSs was an efficient drug delivery vector. It induced the apoptosis of KA cells in vitro and in vivo. Apoptotic staining and DNA fragmentation further demonstrated that the apoptosis rate increased via the treatment of PMS together with VB (VB-PMS) in KA cells, compared with PMS or VB treatment alone. Moreover, VB-PMS activated the expression of apoptosis-related caspase proteins in KA cells. In summary, a novel drug delivery system has been established, and has further been proved that the combination of VB and PMS could improve therapeutic efficacy for leukemia.
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/6667]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Ma, Zhinan,Zhao, Xiaohui,Jiang, Caiyun,et al. Gold Nanoshells with Verbascoside Induce the Apoptosis of Drug-Resistant Leukemia Cells Through Caspases Pathway and Inhibit Tumor Growth[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016.
APA	Ma, Zhinan,Zhao, Xiaohui,Jiang, Caiyun,Yu, Jun,Wu, Jiangping,&Zeng, Xin.(2016).Gold Nanoshells with Verbascoside Induce the Apoptosis of Drug-Resistant Leukemia Cells Through Caspases Pathway and Inhibit Tumor Growth.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY.
MLA	Ma, Zhinan,et al."Gold Nanoshells with Verbascoside Induce the Apoptosis of Drug-Resistant Leukemia Cells Through Caspases Pathway and Inhibit Tumor Growth".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2016).