Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis

	Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis
	Zheng, Wei ; Wang, Qilan ; Lu, Xiaohua ; Shi, Qiangqiang ; Zou, Junhui ; Tao, Yanduo ; Wang, Pu
刊名	MEDIATORS OF INFLAMMATION
	2016
英文摘要	Dracocephalum heterophyllum (DH) is a Chinese herbal medicine used in treating hepatitis. However, the protective effects and pharmacological mechanisms of DH in hepatitis are unknown. In this study, we found that pretreatment with DH extract significantly ameliorated liver injury and suppressed the production of inflammatory cytokines, including tumor necrosis factor (TNF-alpha) and interferon-gamma (IFN-gamma) in ConcanavalinA- (ConA-) induced hepatitis (CIH). DH recruitedmore CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) to the liver and suppressed infiltration of macrophages (Kupffer cells) in the liver. The present work explores DH as an effective hepatoprotective medicine to inhibit inflammation and liver injury caused by hepatitis.
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/6440]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zheng, Wei,Wang, Qilan,Lu, Xiaohua,et al. Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis[J]. MEDIATORS OF INFLAMMATION,2016.
APA	Zheng, Wei.,Wang, Qilan.,Lu, Xiaohua.,Shi, Qiangqiang.,Zou, Junhui.,...&Wang, Pu.(2016).Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis.MEDIATORS OF INFLAMMATION.
MLA	Zheng, Wei,et al."Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis".MEDIATORS OF INFLAMMATION (2016).