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	Localized flexible integration of high-efficiency surface enhanced raman scattering (sers) monitors into microfluidic channels
	Xu, Bin-Bin1; Ma, Zhuo-Chen1; Wang, Lei1; Zhang, Ran1; Niu, Li-Gang1; Yang, Zhe2; Zhang, Yong-Lai1; Zheng, Wan-Hua3; Zhao, Bing2; Xu, Ying1
刊名	Lab on a chip
	2011
卷号	11期号:19页码:3347-3351
ISSN号	1473-0197
DOI	10.1039/c1lc20397e
通讯作者	Xia, hong(hxia@jlu.edu.cn)
英文摘要	We report here a facile approach for flexible integration of high efficiency surface enhanced raman scattering (sers) monitors in a continuous microfluidic channel. in our work, femtosecond laser direct writing was adopted for highly localizable and controllable fabrication of the sers monitor through a multi-photon absorption (mpa) induced photoreduction of silver salt solution. the silver substrate could be shaped into designed patterns, and could be precisely located at the desired position of the microchannel bed, giving the feasibility for real-time detection during reactions. sem and tem images show that the silver substrates were composed of crystallized silver nanoplates with an average thickness of 50 nm. afm results reveal that the substrates were about 600 nm in height and the surface was very rough. as representative tests for sers detection, p-aminothiophenol (p-atp) and flavin adenine dinucleotide (fad) were chosen as probing molecules for microfluidic analysis at visible light (514.5 nm) excitation, exhibiting an enhancement factor of similar to 10(8). in addition, the combination of the sers substrate with the microfluidic channel allows detection of inactive analytes through in situ microfluidic reactions.
WOS关键词	MICROCHIP ELECTROPHORESIS ; RESONANCE RAMAN ; SINGLE-MOLECULE ; GLUCOSE-OXIDASE ; SILVER ; CHIP ; SPECTROSCOPY ; NANOPARTICLES ; SPECTROMETRY ; FABRICATION
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics
WOS类目	Biochemical Research Methods ; Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000294503200019
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2428328
专题	半导体研究所
通讯作者	Xia, Hong
作者单位	1.Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Peoples R China 2.Jilin Univ, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China 3.Chinese Acad Sci, Inst Semicond, Beijing 100083, Peoples R China 4.Jilin Univ, Coll Phys, Changchun 130012, Peoples R China
推荐引用方式 GB/T 7714	Xu, Bin-Bin,Ma, Zhuo-Chen,Wang, Lei,et al. Localized flexible integration of high-efficiency surface enhanced raman scattering (sers) monitors into microfluidic channels[J]. Lab on a chip,2011,11(19):3347-3351.
APA	Xu, Bin-Bin.,Ma, Zhuo-Chen.,Wang, Lei.,Zhang, Ran.,Niu, Li-Gang.,...&Sun, Hong-Bo.(2011).Localized flexible integration of high-efficiency surface enhanced raman scattering (sers) monitors into microfluidic channels.Lab on a chip,11(19),3347-3351.
MLA	Xu, Bin-Bin,et al."Localized flexible integration of high-efficiency surface enhanced raman scattering (sers) monitors into microfluidic channels".Lab on a chip 11.19(2011):3347-3351.

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