Localized flexible integration of high-efficiency surface enhanced raman scattering (sers) monitors into microfluidic channels | |
Xu, Bin-Bin1; Ma, Zhuo-Chen1; Wang, Lei1; Zhang, Ran1; Niu, Li-Gang1; Yang, Zhe2; Zhang, Yong-Lai1; Zheng, Wan-Hua3; Zhao, Bing2; Xu, Ying1 | |
刊名 | Lab on a chip
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2011 | |
卷号 | 11期号:19页码:3347-3351 |
ISSN号 | 1473-0197 |
DOI | 10.1039/c1lc20397e |
通讯作者 | Xia, hong(hxia@jlu.edu.cn) |
英文摘要 | We report here a facile approach for flexible integration of high efficiency surface enhanced raman scattering (sers) monitors in a continuous microfluidic channel. in our work, femtosecond laser direct writing was adopted for highly localizable and controllable fabrication of the sers monitor through a multi-photon absorption (mpa) induced photoreduction of silver salt solution. the silver substrate could be shaped into designed patterns, and could be precisely located at the desired position of the microchannel bed, giving the feasibility for real-time detection during reactions. sem and tem images show that the silver substrates were composed of crystallized silver nanoplates with an average thickness of 50 nm. afm results reveal that the substrates were about 600 nm in height and the surface was very rough. as representative tests for sers detection, p-aminothiophenol (p-atp) and flavin adenine dinucleotide (fad) were chosen as probing molecules for microfluidic analysis at visible light (514.5 nm) excitation, exhibiting an enhancement factor of similar to 10(8). in addition, the combination of the sers substrate with the microfluidic channel allows detection of inactive analytes through in situ microfluidic reactions. |
WOS关键词 | MICROCHIP ELECTROPHORESIS ; RESONANCE RAMAN ; SINGLE-MOLECULE ; GLUCOSE-OXIDASE ; SILVER ; CHIP ; SPECTROSCOPY ; NANOPARTICLES ; SPECTROMETRY ; FABRICATION |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics |
WOS类目 | Biochemical Research Methods ; Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology |
语种 | 英语 |
出版者 | ROYAL SOC CHEMISTRY |
WOS记录号 | WOS:000294503200019 |
内容类型 | 期刊论文 |
URI标识 | http://www.corc.org.cn/handle/1471x/2428328 |
专题 | 半导体研究所 |
通讯作者 | Xia, Hong |
作者单位 | 1.Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Peoples R China 2.Jilin Univ, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China 3.Chinese Acad Sci, Inst Semicond, Beijing 100083, Peoples R China 4.Jilin Univ, Coll Phys, Changchun 130012, Peoples R China |
推荐引用方式 GB/T 7714 | Xu, Bin-Bin,Ma, Zhuo-Chen,Wang, Lei,et al. Localized flexible integration of high-efficiency surface enhanced raman scattering (sers) monitors into microfluidic channels[J]. Lab on a chip,2011,11(19):3347-3351. |
APA | Xu, Bin-Bin.,Ma, Zhuo-Chen.,Wang, Lei.,Zhang, Ran.,Niu, Li-Gang.,...&Sun, Hong-Bo.(2011).Localized flexible integration of high-efficiency surface enhanced raman scattering (sers) monitors into microfluidic channels.Lab on a chip,11(19),3347-3351. |
MLA | Xu, Bin-Bin,et al."Localized flexible integration of high-efficiency surface enhanced raman scattering (sers) monitors into microfluidic channels".Lab on a chip 11.19(2011):3347-3351. |
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