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	Implantable cmos neuro-stimulus chip for visual prosthesis
	Zhang Xu1; Pei WeiHua1; Huang BeiJu1; Wang ShuJing1; Guan Ning1; Guo Kai1; Wang Yu1; Gui Qiang1; Chen Jin1; Wang Kai2
刊名	Science china-information sciences
	2011-04-01
卷号	54期号:4页码:898-908
关键词	Biomedical microelectronics Visual prosthesis Functional electrical stimulation Acute animal experiment Electrical evoked potential (eep) test
ISSN号	1674-733X
DOI	10.1007/s11432-010-4175-6
通讯作者	Zhang xu(zhangxu@semi.ac.cn)
英文摘要	A prototype chip with 2x2 pixels for implanting in blind patients affected by outer retinal degeneration is presented in this paper. this visual prosthesis chip imitates the degenerated photoreceptor cells, senses the incident light and stimulates the remaining healthy layers of retina or optic nerve. each pixel integrates photodiode and stimulus pulse generator, converting the illumination on the eyes into 3-bit resolution bi-phasic current pulses. on-chip charge cancellation modules are used to discharge each electrode site for tissue safety. the prototype chip is designed and fabricated in 0.18-mu m n-well cmos (complementary metal oxide semiconductor) 1p6m mix-signal process, with a +/- 2.5 v dual voltage supply. the functionality of the fabricated chip is demonstrated on anesthetized rabbits. neural responses in visual cortex are successfully evoked by the neuro-stimulus chip through an on-board trigger interface and flexible electrode.
WOS关键词	RETINAL PROSTHESIS ; STIMULATION ; DEVICE ; BLIND
WOS研究方向	Computer Science
WOS类目	Computer Science, Information Systems
语种	英语
出版者	SCIENCE CHINA PRESS
WOS记录号	WOS:000289902100017
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2428178
专题	半导体研究所
通讯作者	Zhang Xu
作者单位	1.Chinese Acad Sci, Inst Semicond, State Key Lab Integrated Optoelect, Beijing 100083, Peoples R China 2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China 3.Peking Univ, Dept Epidemiol & Biostat, Hlth Sci Ctr, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Zhang Xu,Pei WeiHua,Huang BeiJu,et al. Implantable cmos neuro-stimulus chip for visual prosthesis[J]. Science china-information sciences,2011,54(4):898-908.
APA	Zhang Xu.,Pei WeiHua.,Huang BeiJu.,Wang ShuJing.,Guan Ning.,...&Chen HongDa.(2011).Implantable cmos neuro-stimulus chip for visual prosthesis.Science china-information sciences,54(4),898-908.
MLA	Zhang Xu,et al."Implantable cmos neuro-stimulus chip for visual prosthesis".Science china-information sciences 54.4(2011):898-908.

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