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	Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors
	Jin, Wu-Yang; Liu, Zhuo; Liu, Dong; Yu, Long-Chuan1
刊名	Brain research
	2010-03-12
卷号	1320页码:16-21
关键词	Antinociceptive effect Central nucleus of amygdala (cea) Galanin Hindpaw withdrawal latency Mu-opioid receptor Delta-opioid receptor
ISSN号	0006-8993
DOI	10.1016/j.brainres.2009.12.060
通讯作者	Yu, long-chuan(yulc@pku.edu.cn)
英文摘要	The central nucleus of amygdala (cea) is a very important brain structure involved in multiple physiological functions, especially in pain modulation. there are high densities of galanin and galanin receptors found in the cea. the present study was performed to explore the antinociceptive effects of galanin in the cea of rats, and possible involvements of opioid receptors in the galanin-induced antinociception. intra-cea injection of galanin induced dose-dependent increases in hindpaw withdrawal latencies (hwls) to noxious thermal and mechanical stimulations in rats. interestingly, the amtinociceptive effect induced by intra-cea injection of galanin was blocked by intra-cea injection of naloxone, a common opioid receptor antagonist, indicating an involvement of opioid receptors in the galanin-induced antinociception in the cea of rats. moreover, intra-cea injection of either selective mu-opioid receptor antagonist beta-funaltrexamine (beta-fna) or delta-opioid receptor antagonist naltrindole, but not kappa-opioid receptor antagonist nor-binaltorphimine (nor-bni), significantly attenuated the galanin-induced increases in hwls in the cea of rats. taken together, the results demonstrate that galanin induces antinociceptive effects in the cea of rats, and both mu- and delta-opioid receptors are involved in the galanin-induced antinociception. (c) 2009 elsevier b.v. all rights reserved.
WOS关键词	CENTRAL-NERVOUS-SYSTEM ; GENE-RELATED PEPTIDE ; ARCUATE NUCLEUS ; SPINAL ANTINOCICEPTION ; PERIAQUEDUCTAL GREY ; MESSENGER-RNA ; PREOPTIC AREA ; INTACT RATS ; PAIN ; HYPOTHALAMUS
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000275451000003
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2413726
专题	中国科学院大学
通讯作者	Yu, Long-Chuan
作者单位	1.Peking Univ, Coll Life Sci, Neurobiol Lab, Beijing 100871, Peoples R China 2.Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Jin, Wu-Yang,Liu, Zhuo,Liu, Dong,et al. Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors[J]. Brain research,2010,1320:16-21.
APA	Jin, Wu-Yang,Liu, Zhuo,Liu, Dong,&Yu, Long-Chuan.(2010).Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors.Brain research,1320,16-21.
MLA	Jin, Wu-Yang,et al."Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors".Brain research 1320(2010):16-21.

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