QQ客服 官方微博 反馈留言

	Regulation of fasting fuel metabolism by toll-like receptor 4
	Pang, Shanshan; Tang, Haiqing; Zhuo, Shu; Zang, Ying Qin; Le, Yingying1
刊名	Diabetes
	2010-12-01
卷号	59期号:12页码:3041-3048
ISSN号	0012-1797
DOI	10.2337/db10-0418
通讯作者	Le, yingying(yyle@sibs.ac.cn)
英文摘要	Objective toll-like receptor 4 (tlr4) has been reported to induce insulin resistance through inflammation in high-fat-fed mice. however, the physiological role of tlr4 in metabolism is unknown. here, we investigated the involvement of tlr4 in fasting metabolism. research design and methods wild-type and tlr4 deficient (tlr4(-/-)) mice were either fed or fasted for 24 h. glucose and lipid levels in circulation and tissues were measured. glucose and lipid metabolism in tissues, as well as the expression of related enzymes, was examined. results mice lacking tlr4 displayed aggravated fasting hypoglycemia, along with normal hepatic gluconeogenesis, but reversed activity of pyruvate dehydrogenase complex (pdc) in skeletal muscle, which might account for the fasting hypoglycemia. tlr4(-/-) mice also exhibited higher lipid levels in circulation and skeletal muscle after fasting and reversed expression of lipogenic enzymes in skeletal muscle but not liver and adipose tissue. adipose tissue lipolysis is normal and muscle fatty acid oxidation is increased in tlr4(-/-) mice after fasting. inhibition of fatty acid synthesis in tlr4(-/-) mice abolished hyperlipidemia, hypoglycemia, and pdc activity increase, suggesting that tlr4-dependent inhibition of muscle lipogenesis may contribute to glucose and lipid homeostasis during fasting. further studies showed that tlr4 deficiency had no effect on insulin signaling and muscle proinflammatory cytokine production in response to fasting. conclusions these data suggest that tlr4 plays a critical role in glucose and lipid metabolism independent of insulin during fasting and identify a novel physiological role for tlr4 in fuel homeostasis. diabetes 59:3041-3048, 2010
WOS关键词	PYRUVATE-DEHYDROGENASE COMPLEX ; FATTY-ACID SYNTHESIS ; INDUCED INSULIN-RESISTANCE ; HEPATIC LIPID-METABOLISM ; DIETARY GLUCOSE CARBON ; WHITE ADIPOSE-TISSUE ; OB-OB MICE ; PPAR-ALPHA ; DIABETES-MELLITUS ; SKELETAL-MUSCLES
WOS研究方向	Endocrinology & Metabolism
WOS类目	Endocrinology & Metabolism
语种	英语
出版者	AMER DIABETES ASSOC
WOS记录号	WOS:000285988200009
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2413675
专题	中国科学院大学
通讯作者	Le, Yingying
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Pang, Shanshan,Tang, Haiqing,Zhuo, Shu,et al. Regulation of fasting fuel metabolism by toll-like receptor 4[J]. Diabetes,2010,59(12):3041-3048.
APA	Pang, Shanshan,Tang, Haiqing,Zhuo, Shu,Zang, Ying Qin,&Le, Yingying.(2010).Regulation of fasting fuel metabolism by toll-like receptor 4.Diabetes,59(12),3041-3048.
MLA	Pang, Shanshan,et al."Regulation of fasting fuel metabolism by toll-like receptor 4".Diabetes 59.12(2010):3041-3048.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。