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	Synthesis of terpyridine-functionalized poly (n-isopropylacylamide) s and their metal complexes
	Sun Peijian1,2; Shi Xudong1; Gan Zhihua1
刊名	Acta polymerica sinica
	2010-04-20
期号	4页码:383-389
关键词	Raft Poly(n-isopropylacyamide) Terpyridine Thermo-sensitive Therapeutic isotopes
ISSN号	1000-3304
通讯作者	Sun peijian()
英文摘要	A new terpyridine-functionalized dithioester was synthesized as a chain transfer agent in the reversible addition fragmentation chain transfer polymerization (raft) of n-isopropylacyamide (nipaam). the polymerization showed an first-order kinetics and the molecular weight increased linearly with conversion, indicating that the terpyridine-functionalized dithioester is an efficient chain transfer agent for the raft polymerization of nipaam. the terpyridine-functionalized poly (n-isopropylacyamide) (tpy-pnipaam) not only displays similar phase transition as pnipaam, but also have the coordination ability via terpyridine, which were further used to construct macromolecular-metal complex with ferrous ions as model metal ions. the appearance of a strong absorption at 555 nm in uv-vis spectrum revealed the formation of macromolecular-metal complex, indicating the strong coordination ability of tpy-pnipaam to metal. cloud point method and dynamic light scattering (dls) were used to characterize the thermosensitivity of tpy-pnipaam and macromolecular-metal complex. the results showed that the macromolecular-metal complex could self-assemble into nanoparticles in aqueous solution due to the amphiphilic property the macromolecular-metal complex solution showed a similar phase transition as pnipaam. in addition, the nanoparticles of the macromolecular-metal complex in aqueous solution were stable even at temperature above the lower critical solution temperature (lcst) due to electrostatic repulsion. this work indicated the great potentials of tpy-pnipaam as carriers for the delivery of therapeutic radioisotopes.
WOS关键词	COPOLYMERS ; RAFT
WOS研究方向	Polymer Science
WOS类目	Polymer Science
语种	英语
出版者	SCIENCE CHINA PRESS
WOS记录号	WOS:000277591700001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2413607
专题	中国科学院大学
通讯作者	Sun Peijian
作者单位	1.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Sun Peijian,Shi Xudong,Gan Zhihua. Synthesis of terpyridine-functionalized poly (n-isopropylacylamide) s and their metal complexes[J]. Acta polymerica sinica,2010(4):383-389.
APA	Sun Peijian,Shi Xudong,&Gan Zhihua.(2010).Synthesis of terpyridine-functionalized poly (n-isopropylacylamide) s and their metal complexes.Acta polymerica sinica(4),383-389.
MLA	Sun Peijian,et al."Synthesis of terpyridine-functionalized poly (n-isopropylacylamide) s and their metal complexes".Acta polymerica sinica .4(2010):383-389.

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