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	The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an egfr neutralizing antibody
	Han, Qianqian2,3; Jin, Wei1; Xiao, Zhifeng2; Ni, Hongbin1; Wang, Jinhuan4; Kong, Jie1; Wu, Jun1; Liang, Weibang1; Chen, Lei2; Zhao, Yannan2
刊名	Biomaterials
	2010-12-01
卷号	31期号:35页码:9212-9220
关键词	Collagen Egfr neutralizing antibody Spinal cord injury Nerve regeneration
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2010.08.040
通讯作者	Liang, weibang(lwbnj@yahoo.com.cn)
英文摘要	In the treatment of spinal cord injury, implantation of scaffolding biomaterials and the addition of neuroprotective factors will promote neural regeneration. it has been demonstrated in our previous work that linear ordered collagen scaffold (locs) will bridge neural regeneration after the injury of spinal cord hemisection, and bdnf fused with a collagen binding domain (cbd-bdnf) can bind to collagen specifically to exert the neuroprotective effect. besides neuroprotective factors, the lack of axon regeneration of the injured spinal cord has been attributed partially to regeneration inhibitors such as myelin associated proteins and chondroitin sulfate proteoglycans (cspgs). epidermal growth factor receptor (egfr) activation is downstream of the signaling pathways of these inhibitors. here, the monoclonal antibody, 151igg that inhibits signaling of egfr was used to neutralize egfr. 151igg was cross-linked to locs and cbd-bdnf bound to locs to make a triple-functional biomaterial for neural regeneration (bridging, prompting growth and neutralizing growth inhibitors). this triple-functional device was tested in a 6 mm transected sci model. results showed that this collagen scaffold with the addition of 151igg and cbd-bdnf provided effective bridging and stimulation effects for neural regeneration, recovery of electrical transmission of synapses and preventing the formation of glial scars in the extreme transected rat sci model. (c) 2010 elsevier ltd. all rights reserved.
WOS关键词	MYELIN-ASSOCIATED GLYCOPROTEIN ; EPIDERMAL-GROWTH-FACTOR ; CENTRAL-NERVOUS-SYSTEM ; AXON REGENERATION ; FUNCTIONAL RECOVERY ; NEURITE OUTGROWTH ; ADULT-RAT ; MONOCLONAL-ANTIBODY ; WHITE-MATTER ; RECEPTOR
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000284393300008
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2413338
专题	中国科学院大学
通讯作者	Liang, Weibang
作者单位	1.Nanjing Univ, Dept Neurosurg, Affiliated Drum Tower Hosp, Sch Med, Nanjing 210008, Peoples R China 2.Chinese Acad Sci, Key Lab Mol Dev Biol, Inst Genet & Dev Biol, Beijing 100080, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China 4.Tianjing Huanhu Hosp, Inst Neurosurg, Tianjin 300060, Peoples R China
推荐引用方式 GB/T 7714	Han, Qianqian,Jin, Wei,Xiao, Zhifeng,et al. The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an egfr neutralizing antibody[J]. Biomaterials,2010,31(35):9212-9220.
APA	Han, Qianqian.,Jin, Wei.,Xiao, Zhifeng.,Ni, Hongbin.,Wang, Jinhuan.,...&Dai, Jianwu.(2010).The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an egfr neutralizing antibody.Biomaterials,31(35),9212-9220.
MLA	Han, Qianqian,et al."The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an egfr neutralizing antibody".Biomaterials 31.35(2010):9212-9220.

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