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	Evaluation of blid and loc399959 as candidate genes for high myopia in the chinese han population
	Zhao, Fuxin1,2,4,5,6; Bai, Jian3,7; Chen, Wei3,7; Xue, Anquan1,2,4,5,6; Li, Chaohua3; Yan, Zhonghui8; Chen, Hui9; Lu, Fan1,2,4,5,6; Hu, Yongwu1,2,4,5,6; Qu, Jia1,2,4,5,6
刊名	Molecular vision
	2010-10-02
卷号	16期号:209-12页码:1920-1927
ISSN号	1090-0535
通讯作者	Zhou, xiangtian(zxt-dr@wz.zj.cn)
英文摘要	Purpose: bh3-like motif containing, cell death inducer (blid) and loc399959 are two genes associated with the single nucleotide polymorphism (snp) rs577948, which is a susceptibility locus for high myopia in japanese subjects. the purpose of this study was to determine if blid and loc399959 are associated with high myopia in chinese han subjects. methods: high myopia subjects (n=476) had a spherical refractive error of less than -6.00 d in at least one eye and/or an axial length greater than 26 mm. genomic dna was extracted and genotyped from peripheral blood leukocytes of high myopes and controls (n=275). using a case-control association study of candidate regions, linkage disequilibrium blocks for 19 tag snps (tsnps), including rs577948, harbored within and surrounding the blid and loc399959 genes were analyzed on a massarray platform using iplex chemistry. each of the tsnps had an r(2)>0.8 and minor allele frequency >10% in the chinese han population. haplotype association analysis was performed on haploview 4.1 using chi-square (chi(2)) tests. results: none of the 19 tsnps were statistically associated with high myopia. conclusions: while rs577948 may be associated with high myopia in japanese subjects, it and the other tsnps near the blid and loc399959 genes are not susceptibility loci for high myopia in the chinese han population. thus, associations of snps with high myopia as determined by genome-wide association study (gwas) may be restricted to certain ethnic or genetically distinct populations. without systematic replication in other populations, the results of gwas associations should be interpreted with great caution.
WOS关键词	GENOME-WIDE ASSOCIATION ; FACTOR-H POLYMORPHISM ; RECESSIVE HIGH MYOPIA ; HIGH-GRADE MYOPIA ; MACULAR DEGENERATION ; SUSCEPTIBILITY LOCI ; REFRACTIVE ERRORS ; HAPLOTYPE MAP ; RISK-FACTORS ; LINKAGE
WOS研究方向	Biochemistry & Molecular Biology ; Ophthalmology
WOS类目	Biochemistry & Molecular Biology ; Ophthalmology
语种	英语
出版者	MOLECULAR VISION
WOS记录号	WOS:000283715000001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2412608
专题	中国科学院大学
通讯作者	Zhou, Xiangtian
作者单位	1.Wenzhou Med Coll, Sch Ophthalmol & Optometry, Wenzhou 325003, Zhejiang, Peoples R China 2.Wenzhou Med Coll, Hosp Eye, Wenzhou 325003, Zhejiang, Peoples R China 3.Chinese Acad Sci, Key Lab Genome Sci & Informat, Beijing Inst Genom, Beijing, Peoples R China 4.Minist Hlth PR China, State Key Lab Cultivat Base, Wenzhou, Zhejiang, Peoples R China 5.Minist Hlth PR China, Key Lab Vis Sci, Wenzhou, Zhejiang, Peoples R China 6.Zhejiang Prov Key Lab Ophthalmol & Optometry, Wenzhou, Zhejiang, Peoples R China 7.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 8.Eye Hosp Shenzhen, Dept Ophthalmol, Shenzhen, Guangdong, Peoples R China 9.Nantong Univ, Affiliated Hosp, Dept Ophthalmol, Nantong, Jiangshu, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Fuxin,Bai, Jian,Chen, Wei,et al. Evaluation of blid and loc399959 as candidate genes for high myopia in the chinese han population[J]. Molecular vision,2010,16(209-12):1920-1927.
APA	Zhao, Fuxin.,Bai, Jian.,Chen, Wei.,Xue, Anquan.,Li, Chaohua.,...&Zhou, Xiangtian.(2010).Evaluation of blid and loc399959 as candidate genes for high myopia in the chinese han population.Molecular vision,16(209-12),1920-1927.
MLA	Zhao, Fuxin,et al."Evaluation of blid and loc399959 as candidate genes for high myopia in the chinese han population".Molecular vision 16.209-12(2010):1920-1927.

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