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	Decreased serum levels of thioredoxin in patients with coronary artery disease plus hyperhomocysteinemia is strongly associated with the disease severity
	Wu, Yunfei1; Yang, Lijuan2; Zhong, Liangwei1
刊名	Atherosclerosis
	2010-09-01
卷号	212期号:1页码:351-355
关键词	Coronary artery disease Homocysteine Thioredoxin Thioredoxin reductase Human serum
ISSN号	0021-9150
DOI	10.1016/j.atherosclerosis.2010.06.002
通讯作者	Zhong, liangwei(liazho@gucas.ac.cn)
英文摘要	Objective: elevation of homocysteine and thioredoxin (trx) levels was found in some patients with coronary artery diseases (cad). however, their correlations with cad were not clear. dysfunction of thioredoxin/thioredoxin reductase (trxr) may cause oxidative stress that is common to cad. we seek to determine the association among homocysteine, trx/trxr and cad. methods: serum samples were collected from 150 cad patients under statin treatment and 122 non-cad controls. risk factors for atherosclerosis including homocysteine, lipids and glucose levels were analyzed. trx/trxr activities and protein levels were determined using super-insulin assay and western blot, respectively. one-way anova, tukey's post hoc test and spearman's rank correlation coefficient were used for statistical analysis. cad severity was evaluated by angiographic gensini score. results: compared with non-cad group, cad group had significantly increased trxr activity (p < 0.05) and homocysteine levels (p < 0.01), but not trxactivity. after further dividing cad group using homocysteine below 15 mu m asreference, trx activity decreased significantly in cad group with high homocysteine, and was inversely associated with homocysteine levels (r = -0.199, p < 0.05) that was, however, weakly positively associated with trxr activity. neither lipids nor glucose significantly affected trx/trxr activity. association of cad severity with low trx plus high homocysteine was strong (r = -0.458, p < 0.001), but with high homocysteine alone was rather weak (r = 0.125, p = 0.225). conclusion: in cad patients, high homocysteine levels may cause low trx activity, which is closely correlated to the extent and severity of cad. (c) 2010 elsevier ireland ltd. all rights reserved.
WOS关键词	OXIDATIVE STRESS ; UP-REGULATION ; REDUCTASE ; HOMOCYSTEINE ; GLUTATHIONE ; SYSTEMS ; GLUTAREDOXIN ; ACTIVATION ; MECHANISMS ; SECRETION
WOS研究方向	Cardiovascular System & Cardiology
WOS类目	Peripheral Vascular Disease
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000281459900057
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2411887
专题	中国科学院大学
通讯作者	Zhong, Liangwei
作者单位	1.Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing 100853, Peoples R China
推荐引用方式 GB/T 7714	Wu, Yunfei,Yang, Lijuan,Zhong, Liangwei. Decreased serum levels of thioredoxin in patients with coronary artery disease plus hyperhomocysteinemia is strongly associated with the disease severity[J]. Atherosclerosis,2010,212(1):351-355.
APA	Wu, Yunfei,Yang, Lijuan,&Zhong, Liangwei.(2010).Decreased serum levels of thioredoxin in patients with coronary artery disease plus hyperhomocysteinemia is strongly associated with the disease severity.Atherosclerosis,212(1),351-355.
MLA	Wu, Yunfei,et al."Decreased serum levels of thioredoxin in patients with coronary artery disease plus hyperhomocysteinemia is strongly associated with the disease severity".Atherosclerosis 212.1(2010):351-355.

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