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	Lysine acetylation regulates bruton's tyrosine kinase in b cell activation
	Liu, Zhijian1,3,4; Mai, Antonello4,5; Sun, Jian1,2
刊名	Journal of immunology
	2010
卷号	184期号:1页码:244-254
ISSN号	0022-1767
DOI	10.4049/jimmunol.0902324
通讯作者	Sun, jian(jsun@sibs.ac.cn)
英文摘要	Bruton's tyrosine kinase (btk) is essential for bcr signal transduction and has diverse functions in b cells. although btk has been extensively studied, the role of lysine acetylation in btk regulation has not been reported. in this study, we show that bcr cross-linking induces histone lysine acetylation at the btk promoter, correlating with marked recruitment of histone acetyltransferase e1a-associated 300-kda protein (p300) to the locus. these effects enhance btk promoter activity and increase the expression of btk mrna and protein. consistent with these results, activated b cells display increased p300 expression and total histone acetyltransferase activity in vitro and in vivo, resulting in global histone acetylation. interestingly, we found that bcr signaling induces btk lysine acetylation mediated by p300. moreover, lysine acetylation of btk promotes its phosphorylation. together, our results indicate a novel regulatory mechanism for btk transcription and reveal a previously unrecognized posttranslational modification of the btk protein and its association with phosphorylation in b cell activation. the journal of immunology, 2010, 184: 244-254.
WOS关键词	HISTONE DEACETYLASE INHIBITORS ; TRANSCRIPTION FACTORS ; REGION CHROMATIN ; BTK PROMOTER ; CLASS-II ; EXPRESSION ; PROTEIN ; IMMUNODEFICIENCY ; APOPTOSIS ; BINDING
WOS研究方向	Immunology
WOS类目	Immunology
语种	英语
出版者	AMER ASSOC IMMUNOLOGISTS
WOS记录号	WOS:000272985300029
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2410688
专题	中国科学院大学
通讯作者	Sun, Jian
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Biol Sci, Lab B Cell & Autoantibody,Inst Hlth Sci, Shanghai 200025, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Shanghai Inst Immunol, Shanghai 200025, Peoples R China 3.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 5.Univ Roma La Sapienza, Dipartimento Studi Farmaceut, I-00185 Rome, Italy
推荐引用方式 GB/T 7714	Liu, Zhijian,Mai, Antonello,Sun, Jian. Lysine acetylation regulates bruton's tyrosine kinase in b cell activation[J]. Journal of immunology,2010,184(1):244-254.
APA	Liu, Zhijian,Mai, Antonello,&Sun, Jian.(2010).Lysine acetylation regulates bruton's tyrosine kinase in b cell activation.Journal of immunology,184(1),244-254.
MLA	Liu, Zhijian,et al."Lysine acetylation regulates bruton's tyrosine kinase in b cell activation".Journal of immunology 184.1(2010):244-254.

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