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	Meta-analysis added power to identify variants in fto associated with type 2 diabetes and obesity in the asian population
	Liu, Yun1,2,3; Liu, Zhe1,2; Song, Yiqing4,5; Zhou, Daizhan1,2; Zhang, Di1,2; Zhao, Teng1,2; Chen, Zhuo1,2; Yu, Lan1,2; Yang, Yifeng1,2; Feng, Guoyin2
刊名	Obesity
	2010-08-01
卷号	18期号:8页码:1619-1624
ISSN号	1930-7381
DOI	10.1038/oby.2009.469
通讯作者	Xu, he(hexuc@yahoo.com.cn)
英文摘要	Several common variants in the intron 1 of fto (fat mass and associated obesity) gene have been reliably associated with bmi and obesity in european populations. we analyzed two variants (rs9939609 and rs8050136) in 4,189 chinese han individuals and conducted a meta-analysis of published studies in asian population to investigate whether these variants are associated with type 2 diabetes (t2d) and obesity in asian population. in this study, both the minor allele a of rs9939609 and the minor allele a of rs805136 were associated with increased risk of t2d, independent of measures of bmi; the odds ratios (ors) per copy of the risk allele were 1.19 for rs9939609 (95% confidence interval (ci), 1.04-1.37; p = 0.01) and 1.22 for rs8050136 (95% ci, 1.07-1.40; p = 0.004) after adjusting for age, sex, and bmi. our results also showed association with risk of obesity (rs9939609: or = 1.39 (95% ci 1.04-1.85), p = 0.02; rs8050136: or = 1.45 (95% ci 1.09-1.93), p = 0.01) but no association with overweight. these results were consistent with the pooled results from our meta-analysis study (for diabetes, rs8050136, p = 1.3 x 10(-3); rs9939609, p = 9.8 x 10(-4); for obesity, rs8050136, p = 2.2 x 10(-7); rs9939609, p = 9.0 x 10(-9)). our findings indicate that the two variants (rs9939609 and rs8050136) in the fto gene contribute to obesity and t2d in the asian populations.
WOS关键词	GENOME-WIDE ASSOCIATION ; BODY-MASS INDEX ; INSULIN-RESISTANCE ; FAT MASS ; GENETIC-VARIANTS ; EXTREME OBESITY ; ADULT OBESITY ; RISK ; REPLICATION ; CHINESE
WOS研究方向	Endocrinology & Metabolism ; Nutrition & Dietetics
WOS类目	Endocrinology & Metabolism ; Nutrition & Dietetics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000280392400021
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2409626
专题	中国科学院大学
通讯作者	Xu, He
作者单位	1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China 2.Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China 3.Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China 4.Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA 5.Harvard Univ, Sch Med, Boston, MA USA 6.Fudan Univ, Shanghai Canc Hosp, Dept Thorac Surg, Shanghai 200433, Peoples R China 7.Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA USA 8.Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA 9.Univ Calif Los Angeles, Ctr Metab Dis Prevent, Los Angeles, CA 90024 USA
推荐引用方式 GB/T 7714	Liu, Yun,Liu, Zhe,Song, Yiqing,et al. Meta-analysis added power to identify variants in fto associated with type 2 diabetes and obesity in the asian population[J]. Obesity,2010,18(8):1619-1624.
APA	Liu, Yun.,Liu, Zhe.,Song, Yiqing.,Zhou, Daizhan.,Zhang, Di.,...&Xu, He.(2010).Meta-analysis added power to identify variants in fto associated with type 2 diabetes and obesity in the asian population.Obesity,18(8),1619-1624.
MLA	Liu, Yun,et al."Meta-analysis added power to identify variants in fto associated with type 2 diabetes and obesity in the asian population".Obesity 18.8(2010):1619-1624.

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