| Appl1 is essential for the survival of xertopus pancreas, duodenum, and stomach progenitor cells | |
| Wen, Luan1,5; Yang, Yong1; Wang, Yu1,2,3,4; Xu, Aimin1,2,3,4; Wu, Donghai1; Chen, Yonglong1 | |
| 刊名 | Developmental dynamics
 |
| 2010-08-01 | |
| 卷号 | 239期号:8页码:2198-2207 |
| 关键词 | Xenopus Appl1 Akt2 Pancreas Duodenum Stomach |
| ISSN号 | 1058-8388 |
| DOI | 10.1002/dvdy.22356 |
| 通讯作者 | Wu, donghai(wu_donghai@gibh.ac.cn) |
| 英文摘要 | An understanding of the molecular mechanisms governing the survival of organ progenitor cells in vivo is crucial for in vitro tissue regeneration. here, we have found that xenopus appl1 and akt2 share a similar embryonic expression pattern, showing characteristic expression in the central nervous system as well as in the pancreas and part of the stomach/duodenum (sd) at tadpole stages of development. specific knockdown of appl1 in endoderm or inhibition of akt activity did not affect the formation of endodermal organ primordia at tail bud stages of development, but led to a gut-coiling defect, strong apoptosis in endodermal organs, and pancreas and sd hypoplasia or even aplasia at tadpole stages of development. furthermore, appl1 is required for akt phosphorylation and akt2 in turn can rescue appl1 knockdown phenotypes. together, our data suggest that appl1-akt signaling is specifically required for the survival of pancreas and sd progenitor cells in xenopus laevis embryos. developmental dynamics 239:2198-2207, 2010. (c) 2010 wiley-liss, inc. |
| WOS关键词 | ZINC-FINGER NUCLEASES ; XENOPUS-LAEVIS ; WNT/BETA-CATENIN ; SIGNAL-TRANSDUCTION ; PROTEIN APPL1 ; BETA-CATENIN ; KINASE AKT2 ; ENDODERM ; GENE ; EXPRESSION |
| WOS研究方向 | Anatomy & Morphology ; Developmental Biology |
| WOS类目 | Anatomy & Morphology ; Developmental Biology |
| 语种 | 英语 |
| 出版者 | WILEY-LISS |
| WOS记录号 | WOS:000280716500006 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2409137 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wu, Donghai |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Regenerat Biol, Guangzhou Inst Biomed & Hlth, Guangzhou 510663, Guangdong, Peoples R China 2.Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China 3.Univ Hong Kong, Dept Pharmacol & Pharm, Hong Kong, Hong Kong, Peoples R China 4.Univ Hong Kong, Res Ctr Heart Brain Hormone & Healthy Aging, Hong Kong, Hong Kong, Peoples R China 5.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen, Luan,Yang, Yong,Wang, Yu,et al. Appl1 is essential for the survival of xertopus pancreas, duodenum, and stomach progenitor cells[J]. Developmental dynamics,2010,239(8):2198-2207. |
| APA | Wen, Luan,Yang, Yong,Wang, Yu,Xu, Aimin,Wu, Donghai,&Chen, Yonglong.(2010).Appl1 is essential for the survival of xertopus pancreas, duodenum, and stomach progenitor cells.Developmental dynamics,239(8),2198-2207. |
| MLA | Wen, Luan,et al."Appl1 is essential for the survival of xertopus pancreas, duodenum, and stomach progenitor cells".Developmental dynamics 239.8(2010):2198-2207. |
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