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	Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells
	Gao, Yuan1,2; Wang, Bin1; Xiao, Zhifeng1; Chen, Bing1; Han, Jin1; Wang, Xia1; Zhang, Jing1; Gao, Shaorong3; Zhao, Yannan1; Dai, Jianwu1
刊名	Stem cells and development
	2010
卷号	19期号:1页码:53-60
ISSN号	1547-3287
DOI	10.1089/scd.2008.0357
通讯作者	Dai, jianwu(jwdai@genetics.ac.cn)
英文摘要	Homeodomain transcription factor nanog plays a critical role in maintaining murine embryonic stem (es) cells pluripotency. however, its expression regulation largely remains unknown. in this study we show that nogo receptor (ngr) participates in the regulation of nanog expression via stat3 pathway. activation of ngr results in the phosphorylation of stat3 and increases expression levels of nanog mrna and protein, which inhibits differentiation of embryoid bodies. this up-regulation of nanog can be abolished by ngr inhibitor pi-plc and nep1-40, or phospho-stat3 inhibitor ag490 and rapamycin. immunofluorescence assay demonstrates that ngr and its ligand nogo-a/b exist on mouse blastocysts and cultured es cells, suggesting ngr might play a role in early embryo development.
WOS关键词	SELF-RENEWAL ; TRANSCRIPTIONAL NETWORKS ; AXONAL REGENERATION ; MOUSE EMBRYOS ; ASY/NOGO-B ; PLURIPOTENCY ; DIFFERENTIATION ; PROTEIN ; INHIBITOR ; IDENTIFICATION
WOS研究方向	Cell Biology ; Hematology ; Research & Experimental Medicine ; Transplantation
WOS类目	Cell & Tissue Engineering ; Hematology ; Medicine, Research & Experimental ; Transplantation
语种	英语
出版者	MARY ANN LIEBERT INC
WOS记录号	WOS:000273675300007
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2407111
专题	中国科学院大学
通讯作者	Dai, Jianwu
作者单位	1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China 3.Natl Inst Biol Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Gao, Yuan,Wang, Bin,Xiao, Zhifeng,et al. Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells[J]. Stem cells and development,2010,19(1):53-60.
APA	Gao, Yuan.,Wang, Bin.,Xiao, Zhifeng.,Chen, Bing.,Han, Jin.,...&Dai, Jianwu.(2010).Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells.Stem cells and development,19(1),53-60.
MLA	Gao, Yuan,et al."Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells".Stem cells and development 19.1(2010):53-60.

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