| Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation | |
| Zhang, Zhenguo1,2,3; Zhou, Li1,2,3; Hu, Landian1,2; Zhu, Yufei1,2; Xu, Heng1,2,3; Liu, Yang1,2,3; Chen, Xianfen1,2,3; Yi, Xianfu1,2,3; Kong, Xiangyin1,2,4; Hurst, Laurence D.5 | |
| 刊名 | Molecular systems biology
 |
| 2010-12-01 | |
| 卷号 | 6页码:9 |
| 关键词 | Nonsense-mediated mrna decay Translation efficiency Translation repression |
| ISSN号 | 1744-4292 |
| DOI | 10.1038/msb.2010.101 |
| 通讯作者 | Kong, xiangyin(xykong@sibs.ac.cn) |
| 英文摘要 | Nonsense-mediated mrna decay (nmd) is a surveillance system that eliminates transcripts with premature termination codons. in this study, we show that mrnas targeted by nmd are also suppressed at the translational level. the low translational efficiency (te) is a consequence of multiple features acting in concert, including low translation initiation rate, mediated by 5` secondary structure and by use of weak initiation sites, and low translation elongation speed, mediated by low codon usage bias. despite low elongation rates, nmd transcripts show low ribosome density in the coding sequence, probably owing to low initiation rates, high abortion rates or rapid transit of the ribosome following initiation failure. the low te is observed in the absence of nmd and is not explained by low transcript abundance. translational inefficiency is flexible, such that nmd targets have increased te upon starvation. we propose that the low te predisposes to nmd and/or that it is part of a mechanism for regulation of nmd transcripts. molecular systems biology 6: 442; published online 21 december 2010; doi:10.1038/msb.2010.101 |
| WOS关键词 | MESSENGER-RNA DECAY ; GENOME-WIDE ANALYSIS ; CODON USAGE BIAS ; SACCHAROMYCES-CEREVISIAE ; ESCHERICHIA-COLI ; YEAST ; EXPRESSION ; QUANTIFICATION ; EFFICIENCY ; INITIATION |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000285930400001 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2405730 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Kong, Xiangyin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200025, Peoples R China 2.SJTUSM, Shanghai, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 4.Shanghai Jiao Tong Univ, Ruijin Hosp, State Key Lab Med Genom, Shanghai 200030, Peoples R China 5.Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Somerset, England |
| 推荐引用方式 GB/T 7714 | Zhang, Zhenguo,Zhou, Li,Hu, Landian,et al. Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation[J]. Molecular systems biology,2010,6:9. |
| APA | Zhang, Zhenguo.,Zhou, Li.,Hu, Landian.,Zhu, Yufei.,Xu, Heng.,...&Hurst, Laurence D..(2010).Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation.Molecular systems biology,6,9. |
| MLA | Zhang, Zhenguo,et al."Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation".Molecular systems biology 6(2010):9. |
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