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	A wnt-frz/ror-dsh pathway regulates neurite outgrowth in caenorhabditis elegans
	Song, Song1,2; Zhang, Bo1,2; Sun, Hui1; Li, Xia1; Xiang, Yanhui1,2; Liu, Zhonghua1; Huang, Xun1; Ding, Mei1
刊名	Plos genetics
	2010-08-01
卷号	6期号:8页码:12
ISSN号	1553-7390
DOI	10.1371/journal.pgen.1001056
通讯作者	Song, song()
英文摘要	One of the challenges to understand the organization of the nervous system has been to determine how axon guidance molecules govern axon outgrowth. through an unbiased genetic screen, we identified a conserved wnt pathway which is crucial for anterior-posterior (a/p) outgrowth of neurites from rme head motor neurons in caenorhabditis elegans. the pathway is composed of the wnt ligand cwn-2, the frizzled receptors cfz-2 and mig-1, the co-receptor cam-1/ror, and the downstream component dishevelled/dsh-1. among these, cwn-2 acts as a local attractive cue for neurite outgrowth, and its activity can be partially substituted with other wnts, suggesting that spatial distribution plays a role in the functional specificity of wnts. as a co-receptor, cam-1 functions cell-autonomously in neurons and, together with cfz-2 and mig-1, transmits the wnt signal to downstream effectors. yeast two-hybrid screening identified dsh-1 as a binding partner for cam-1, indicating that cam-1 could facilitate cwn-2/wnt signaling by its physical association with dsh-1. our study reveals an important role of a wnt-frz/ror-dsh pathway in regulating neurite a/p outgrowth.
WOS关键词	RECEPTOR TYROSINE KINASE ; ANTERIOR-POSTERIOR GUIDANCE ; C-ELEGANS ; AXON GUIDANCE ; HOMEODOMAIN PROTEIN ; REQUIRES RETROMER ; CELL-MIGRATION ; BETA-CATENIN ; GROWTH CONE ; POLARITY
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
WOS记录号	WOS:000281383800012
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2405508
专题	中国科学院大学
通讯作者	Song, Song
作者单位	1.Chinese Acad Sci, Key Lab Mol & Dev Biol, Inst Genet & Dev Biol, Beijing, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Song, Song,Zhang, Bo,Sun, Hui,et al. A wnt-frz/ror-dsh pathway regulates neurite outgrowth in caenorhabditis elegans[J]. Plos genetics,2010,6(8):12.
APA	Song, Song.,Zhang, Bo.,Sun, Hui.,Li, Xia.,Xiang, Yanhui.,...&Ding, Mei.(2010).A wnt-frz/ror-dsh pathway regulates neurite outgrowth in caenorhabditis elegans.Plos genetics,6(8),12.
MLA	Song, Song,et al."A wnt-frz/ror-dsh pathway regulates neurite outgrowth in caenorhabditis elegans".Plos genetics 6.8(2010):12.

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