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	Erk1/2 promotes proliferation and inhibits neuronal differentiation of neural stem cells
	Wang, Bin1,2; Gao, Yuan1,2; Xiao, Zhifeng1; Chen, Bing1; Han, Jin1; Zhang, Jing1; Wang, Xia1; Dai, Jianwu1,2
刊名	Neuroscience letters
	2009-09-15
卷号	461期号:3页码:252-257
关键词	Neural stem cells Proliferation Differentiation Development Signal
ISSN号	0304-3940
DOI	10.1016/j.neulet.2009.06.020
通讯作者	Dai, jianwu(jwdai@genetics.ac.cn)
英文摘要	Neural stem cells (nscs) are in a complex niche in which cell-extrinsic cues and cell-intrinsic genetic mechanisms in chorus mediate their cellular processes such as self-renewal and differentiation. in this study, we found that inactivation of erk1/2 with u0126 in nscs significantly promoted neuronal differentiation and inhibited proliferation. sustained erk1/2 inactivity was required in this process. we also found that nerve growth factor (ngf) and collagen could promote the proliferation and inhibit neuronal differentiation by activating phosphorylation of erk1/2. cell-cycle regulators such as cyclin-dependent kinase 2 (cdk2), cyclin d1 and hes1 mediated the effect of erk on nscs proliferation and differentiation. our results showed that erk1/2 played an important role in the interplay between cell-extrinsic cues and cell-intrinsic genetic mechanisms in neural stem cell biology. (c) 2009 elsevier ireland ltd. all rights reserved.
WOS关键词	CENTRAL-NERVOUS-SYSTEM ; PRECURSOR CELLS ; CEREBRAL-CORTEX ; KINASE-ACTIVITY ; GROWTH-FACTOR ; SPINAL-CORD ; TRANSPLANTATION ; NEUROGENESIS ; CYCLE ; PROGENITORS
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000268617600010
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2405199
专题	中国科学院大学
通讯作者	Dai, Jianwu
作者单位	1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wang, Bin,Gao, Yuan,Xiao, Zhifeng,et al. Erk1/2 promotes proliferation and inhibits neuronal differentiation of neural stem cells[J]. Neuroscience letters,2009,461(3):252-257.
APA	Wang, Bin.,Gao, Yuan.,Xiao, Zhifeng.,Chen, Bing.,Han, Jin.,...&Dai, Jianwu.(2009).Erk1/2 promotes proliferation and inhibits neuronal differentiation of neural stem cells.Neuroscience letters,461(3),252-257.
MLA	Wang, Bin,et al."Erk1/2 promotes proliferation and inhibits neuronal differentiation of neural stem cells".Neuroscience letters 461.3(2009):252-257.

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