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	Preparation and characterization of a novel ph-sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium
	Wang, Qin1,2; Zhang, Junping1; Wang, Aiqin1
刊名	Carbohydrate polymers
	2009-11-17
卷号	78期号:4页码:731-737
关键词	Composite hydrogel bead Ph-sensitive Controlled release Diclofenac sodium
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2009.06.010
通讯作者	Wang, aiqin(aqwang@lzb.ac.cn)
英文摘要	A series of ph-sensitive composite hydrogel beads composed of chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate (cts-g-paa/apt/sa) was prepared as drug delivery matrices crosslinked by ca(2+) owing to the ionic gelation of sa. the structure and surface morphology of the composite hydrogel beads were characterized by ftir and sem, respectively. ph-sensitivity of these composite hydrogels beads and the release behaviors of drug from them were investigated. the results showed that the composite hydrogel beads had good ph-sensitivity. the cumulative release ratios of diclofenac sodium (ds) from the composite hydrogel beads were 3.76% in ph 2.1 solution and 100% in ph 6.8 solutions within 24h, respectively. however, the cumulative release ratio of ds in ph 7.4 solution reached 100% within 2 h. the ds cumulative release ratio reduced with increasing apt content from 0 to 50 wt%. the drug release was swelling-controlled at ph 6.8. (c) 2009 elsevier ltd. all rights reserved.
WOS关键词	CONTROLLED DRUG-RELEASE ; DELIVERY SYSTEMS ; SUPERABSORBENT COMPOSITES ; MICROSPHERES ; BEHAVIOR ; ACID ; FILM
WOS研究方向	Chemistry ; Polymer Science
WOS类目	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000270624200012
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2404713
专题	中国科学院大学
通讯作者	Wang, Aiqin
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Qin,Zhang, Junping,Wang, Aiqin. Preparation and characterization of a novel ph-sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium[J]. Carbohydrate polymers,2009,78(4):731-737.
APA	Wang, Qin,Zhang, Junping,&Wang, Aiqin.(2009).Preparation and characterization of a novel ph-sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium.Carbohydrate polymers,78(4),731-737.
MLA	Wang, Qin,et al."Preparation and characterization of a novel ph-sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium".Carbohydrate polymers 78.4(2009):731-737.

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