| Ephrina5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor | |
| Li, J-J2; Liu, D-P; Liu, G-T3; Xie, D.1 | |
| 刊名 | Oncogene
 |
| 2009-04-16 | |
| 卷号 | 28期号:15页码:1759-1768 |
| 关键词 | Ephrina5 Egfr C-cbl Glioma |
| ISSN号 | 0950-9232 |
| DOI | 10.1038/onc.2009.15 |
| 通讯作者 | Xie, d.(dxie@sibs.ac.cn) |
| 英文摘要 | Eph receptors, the largest subfamily of receptor tyrosine kinases, and their ephrin ligands play important roles in nervous system development. recently, they have been implicated in tumorigenesis of different cancers. in this study, we showed that the expression of ephrina5 was dramatically downregulated in primary gliomas compared with normal tissues. forced expression of ephrina5 reduced tumorigenicity of human glioma u373 cells. epidermal growth factor receptor (egfr), which frequently acts as an oncoprotein in glioma, was greatly decreased in ephrina5-transfected glioma cells, and the two molecules exhibited a mutually exclusive expression pattern in primary glioma samples. we found that ephrina5 enhanced c-cbl binding to egfr, thus promoted ubiquitylation and degradation of the receptor. either ephrina5-fc or epha2-fc treatment simulating bidirectional signaling of eph/ephrin system resulted in egfr decrease. this study discovered that ephrina5 acted as a tumor suppressor in glioma, and its negative regulation of egfr contributed to the suppressive effects. in addition to identifying a novel mechanism underlying tumor suppressor activity of ephrina5, we also showed cross-talk between different receptor tyrosine kinase families in glioma. these.ndings may improve therapeutic strategies for glioma. |
| WOS关键词 | C-CBL ; EPH RECEPTORS ; TYROSINE KINASES ; GENE-EXPRESSION ; CANCER CELLS ; T-CELLS ; PHOSPHORYLATION ; BINDING ; LIGAND ; TUMORIGENICITY |
| WOS研究方向 | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
| WOS类目 | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000265640400003 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2404260 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xie, D. |
| 作者单位 | 1.Chinese Acad Sci, Mol Oncol Lab, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China 3.Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA |
| 推荐引用方式 GB/T 7714 | Li, J-J,Liu, D-P,Liu, G-T,et al. Ephrina5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor[J]. Oncogene,2009,28(15):1759-1768. |
| APA | Li, J-J,Liu, D-P,Liu, G-T,&Xie, D..(2009).Ephrina5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor.Oncogene,28(15),1759-1768. |
| MLA | Li, J-J,et al."Ephrina5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor".Oncogene 28.15(2009):1759-1768. |
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