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	A discovery of novel micrornas in the silkworm (bombyx mori) genome
	Yu, Xiaomin1; Zhou, Qing1,2; Cai, Yimei1,2; Luo, Qibin1,3; Lin, Hongbin1; Hu, Songnian1; Yu, Jun1
刊名	Genomics
	2009-12-01
卷号	94期号:6页码:438-444
关键词	Silkworm Micrornas Origin Cluster Targets
ISSN号	0888-7543
DOI	10.1016/j.ygeno.2009.08.007
通讯作者	Hu, songnian(husn@big.ac.cn)
英文摘要	Micrornas (mirnas) are pivotal regulators involved in various physiological and pathological processes via their post-transcriptional regulation of gene expressions. we sequenced 14 libraries of small rnas constructed from samples spanning the life cycle of silkworms, and discovered 50 novel mirnas previously not known in animals and verified 43 of them using stem-loop rt-pcr. our genome-wide analyses of 27 species-specific mirnas suggest they arise from transposable elements, protein-coding genes duplication/ transposition and random foldback sequences; which is consistent with the idea that novel animal mirnas may evolve from incomplete self-complementary transcripts and become fixed in the process of co-adaptation with their targets. computational prediction suggests that the silkworm-specific mirnas may have a preference of regulating genes that are related to life-cycle-associated traits, and these genes can serve as potential targets for subsequent studies of the modulating networks in the development of bombyx mori. (c) 2009 elsevier inc. all rights reserved.
WOS关键词	CAENORHABDITIS-ELEGANS ; ARABIDOPSIS-THALIANA ; TRANSPOSABLE ELEMENTS ; DROSOPHILA MICRORNAS ; REGULATORY ROLES ; EVOLUTION ; GENES ; EXPRESSION ; RNAS ; IDENTIFICATION
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000272103600010
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2402860
专题	中国科学院大学
通讯作者	Hu, Songnian
作者单位	1.Chinese Acad Sci, Key Lab Genome Informat & Sci, Beijing Inst Genom, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Tech Univ Munich, Dept Genome Oriented Bioinformat, Wissensch Zentrum, D-85350 Freising Weihenstephan, Germany
推荐引用方式 GB/T 7714	Yu, Xiaomin,Zhou, Qing,Cai, Yimei,et al. A discovery of novel micrornas in the silkworm (bombyx mori) genome[J]. Genomics,2009,94(6):438-444.
APA	Yu, Xiaomin.,Zhou, Qing.,Cai, Yimei.,Luo, Qibin.,Lin, Hongbin.,...&Yu, Jun.(2009).A discovery of novel micrornas in the silkworm (bombyx mori) genome.Genomics,94(6),438-444.
MLA	Yu, Xiaomin,et al."A discovery of novel micrornas in the silkworm (bombyx mori) genome".Genomics 94.6(2009):438-444.

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