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	Anti-diabetic effects of vanadium(iii, iv, v)-chlorodipicolinate complexes in streptozotocin-induced diabetic rats
	Li, Ming1; Ding, Wenjun1; Smee, Jason J.2,4; Baruah, Bharat4; Willsky, Gail R.3; Crans, Debbie C.4
刊名	Biometals
	2009-12-01
卷号	22期号:6页码:895-905
关键词	Vanadium Chlorodipicolinate Insulin-enhancing Lipid Redox Diabetes
ISSN号	0966-0844
DOI	10.1007/s10534-009-9241-4
通讯作者	Ding, wenjun(dingwj@gucas.ac.cn)
英文摘要	Vanadium(iii, iv, v)-chlorodipicolinate (dipic-cl) complexes, including h[v(iii)(dipic-cl)(2)] center dot a 5h(2)o (v(3)dipic-cl), v(iv)o(dipic-cl)(h(2)o)(2) (v(4)dipic-cl) and k[v(v)o(2)(dipic-cl)] (v(5)dipic-cl), were prepared with the indicated oxidation states. our aim was to evaluate the anti-diabetic effects of v(3)dipic-cl, v(4)dipic-cl and v(5)dipic-cl in streptozotocin-induced diabetic rats. vanadium complexes were orally administered to diabetic rats at concentrations of 0.1-0.3 mg/ml in the drinking water. we found that vanadium-chlorodipicolinate (v-dipic-cl) complexes at the concentration of 0.1 mg/ml did not exhibit blood glucose-lowering effects when administered to diabetic rats for 20 days. however, the levels of fasting blood glucose in diabetic rats were decreased after treatment with 0.3 mg/ml of v(4)dipic-cl and v(5)dipic-cl complexes for the following 20 days. although administration of both v(4)dipic-cl and v(5)dipic-cl significantly lowered diabetic hyperglycemia, the vanadium intake from administration of v(4)dipic-cl is nearly 1.5-fold greater compared to that of v(5)dipic-cl. treatment with the h(2)dipic-cl ligand and all three v-dipic-cl complexes significantly lowered serum cholesterol, while administration of the v(5)dipic-cl complex lowered serum cholesterol significantly more than administration of the ligand alone. treatment with ligand alone did not have an effect on serum triglyceride, while administration of the v(4)dipic-cl and v(5)dipic-cl significantly lowered the elevated serum triglyceride associated with diabetes. oral administration of the ligand and all v-dipic-cl complexes did significantly lower diabetes elevated serum alkaline phosphatase. treatment with h(2)dipic-cl ligand and v(4)dipic-cl and v(5)dipiccl significantly lowered diabetes elevated aspartate amino transferase. these results indicate that the health of the treated animals did not seem to be further compromised compared to that of diabetic animals. in addition, oral administration of h(2)dipic-cl, v(3)dipic-cl, v(4)dipic-cl and v(5)dipic-cl did not alter diabetic serum creatinine and blood urea nitrogen levels, suggesting no significant side effects of vanadium treatment on renal functions at the dose of 0.3 mg/ml in diabetic rats. the results presented here suggest that the anti-diabetic effects of treatment with v-dipic-cl complexes were likely associated in part with the oxidation state of vanadium.
WOS关键词	ORAL VANADYL SULFATE ; IN-VIVO ; INSULINOMIMETIC ACTIVITY ; INSULIN SENSITIVITY ; AQUEOUS CHEMISTRY ; SKELETAL-MUSCLE ; GENE-EXPRESSION ; ORGANIC-LIGANDS ; BIS(MALTOLATO)OXOVANADIUM(IV) ; MELLITUS
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000271748400004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2401831
专题	中国科学院大学
通讯作者	Ding, Wenjun
作者单位	1.Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China 2.Univ Texas Tyler, Dept Chem, Tyler, TX 75799 USA 3.SUNY Buffalo, Dept Biochem, Sch Med & Biomed Sci, Buffalo, NY 14214 USA 4.Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA
推荐引用方式 GB/T 7714	Li, Ming,Ding, Wenjun,Smee, Jason J.,et al. Anti-diabetic effects of vanadium(iii, iv, v)-chlorodipicolinate complexes in streptozotocin-induced diabetic rats[J]. Biometals,2009,22(6):895-905.
APA	Li, Ming,Ding, Wenjun,Smee, Jason J.,Baruah, Bharat,Willsky, Gail R.,&Crans, Debbie C..(2009).Anti-diabetic effects of vanadium(iii, iv, v)-chlorodipicolinate complexes in streptozotocin-induced diabetic rats.Biometals,22(6),895-905.
MLA	Li, Ming,et al."Anti-diabetic effects of vanadium(iii, iv, v)-chlorodipicolinate complexes in streptozotocin-induced diabetic rats".Biometals 22.6(2009):895-905.

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