| Visual observation of g-quadruplex dna with the label-free fluorescent probe silole with aggregation-induced emission | |
| Huang, Jing1; Wang, Ming2; Zhou, Yangyang1; Weng, Xiaocheng1; Shuai, Liang1; Zhou, Xiang1; Zhang, Deqing2 | |
| 刊名 | Bioorganic & medicinal chemistry
 |
| 2009-11-15 | |
| 卷号 | 17期号:22页码:7743-7748 |
| 关键词 | Aie Silole G-quadruplex Visual observation |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2009.09.040 |
| 通讯作者 | Zhou, xiang(xzhou@whu.edu.cn) |
| 英文摘要 | Aie molecule silole 1 could be used to detect g-quadruplex formation using an exonuclease i hydrolysis assay. this visual observation of g-quadruplexes has been successfully used in investigating multiple g-quadruplexes, including the one-stranded telomeric, c-myc, c-kit, vegf g-quadruplexes, and a d(g(4)t(4)g(4)) inter-molecular g-quadruplex. the detection of g-quadruplex can be also applied to g-quadruplex isomers induced by small molecules. (c) 2009 elsevier ltd. all rights reserved. |
| WOS关键词 | RESONANCE ENERGY-TRANSFER ; TELOMERIC G-QUADRUPLEX ; TURN-ON DETECTION ; C-MYC PROMOTER ; BINDING LIGANDS ; ASSAY ; TRANSITION ; CANCER ; STABILIZATION ; ANTIPARALLEL |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000271340000013 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2401684 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhou, Xiang |
| 作者单位 | 1.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China 2.Chinese Acad Sci, Grad Sch, Inst Chem, Beijing Natl Lab Mol Sci,Organ Solids Lab, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Jing,Wang, Ming,Zhou, Yangyang,et al. Visual observation of g-quadruplex dna with the label-free fluorescent probe silole with aggregation-induced emission[J]. Bioorganic & medicinal chemistry,2009,17(22):7743-7748. |
| APA | Huang, Jing.,Wang, Ming.,Zhou, Yangyang.,Weng, Xiaocheng.,Shuai, Liang.,...&Zhang, Deqing.(2009).Visual observation of g-quadruplex dna with the label-free fluorescent probe silole with aggregation-induced emission.Bioorganic & medicinal chemistry,17(22),7743-7748. |
| MLA | Huang, Jing,et al."Visual observation of g-quadruplex dna with the label-free fluorescent probe silole with aggregation-induced emission".Bioorganic & medicinal chemistry 17.22(2009):7743-7748. |
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