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	Aml1-eto9a is correlated with c-kit overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-m2
	Jiao, B.2,3; Wu, C-F2,3; Liang, Y.2,3; Chen, H-M2,3; Xiong, S-M2,3; Chen, B.2,3; Shi, J-Y2,3; Wang, Y-Y2,3; Wang, J-H2,3; Chen, Y.2,3
刊名	Leukemia
	2009-09-01
卷号	23期号:9页码:1598-1604
关键词	Aml1-eto Aml1-eto9a C-kit T(8 Acute myeloid leukemia-m2 21)
ISSN号	0887-6924
DOI	10.1038/leu.2009.104
通讯作者	Chen, s-j(sjchen@stn.sh.cn)
英文摘要	Aml1-eto fusion gene is generated from chromosomal translocation t(8;21) mainly in acute myeloid leukemia m2 subtype (aml-m2). its spliced variant transcript, aml1-eto9a, rapidly induces leukemia in murine model. to evaluate its clinical significance, aml1-eto9a expression was assessed in 118 patients with t(8; 21) aml-m2, using qualitative and nested quantitative reverse transcriptase (rt)-pcr methods. these cases were accordingly divided into the aml1-eto9a-h group (n = 86, positive for qualitative rt-pcr, with higher level of aml1-eto9a by quantitative rt-pcr) and the aml1-eto9a-l group (n = 32, negative for qualitative rt-pcr, with lower but still detectable level of aml1-eto9a by quantitative rt-pcr). c-kit expression was significantly increased in the aml1-eto9a-h group, as compared with the aml1-eto9a-l group. of the 36 patients harboring c-kit mutations, 32 patients overexpressed aml1-eto9a (p = 0.0209). clinically, aml1-eto9a-h patients exhibited significantly elevated white blood cells count, less bone marrow aberrant myelocytes, increased cd56 but decreased cd19 expression (p = 0.0451, p = 0.0479, p = 0.0149 and p = 0.0298, respectively). moreover, aml1-eto9a overexpression was related to short event-free and overall survival time (p = 0.0072 and p = 0.0076, respectively). taken together, these data suggest that aml1-eto9a is correlated with c-kit overexpression/mutations and indicates poor disease outcome in t(8;21) aml-m2. leukemia (2009) 23, 1598-1604; doi:10.1038/leu.2009.104; published online 21 may 2009
WOS关键词	RECEPTOR TYROSINE KINASES ; BINDING-FACTOR LEUKEMIAS ; PROGNOSTIC IMPACT ; MUTATIONS ; LEUKEMOGENESIS ; TRANSLOCATION ; AML ; T(8/21)(Q22,Q22) ; DIAGNOSIS ; SURVIVAL
WOS研究方向	Oncology ; Hematology
WOS类目	Oncology ; Hematology
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000269674200008
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2399598
专题	中国科学院大学
通讯作者	Chen, S-J
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, State Key Lab Med Genom, Shanghai Inst Hematol,Rui Jin Hosp, Shanghai 200025, Peoples R China 2.Chinese Acad Sci, State Key Lab Med Genom, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China 3.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Med Ctr, Shanghai 200025, Peoples R China
推荐引用方式 GB/T 7714	Jiao, B.,Wu, C-F,Liang, Y.,et al. Aml1-eto9a is correlated with c-kit overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-m2[J]. Leukemia,2009,23(9):1598-1604.
APA	Jiao, B..,Wu, C-F.,Liang, Y..,Chen, H-M.,Xiong, S-M.,...&Chen, S-J.(2009).Aml1-eto9a is correlated with c-kit overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-m2.Leukemia,23(9),1598-1604.
MLA	Jiao, B.,et al."Aml1-eto9a is correlated with c-kit overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-m2".Leukemia 23.9(2009):1598-1604.

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