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	Property and application of novel ferrocenyl-azobenzene labeled peptide nucleic acid monomers with the dual stimulus-response characteristics
	Liu, Sheng1,2; Wang, Jinqing1; Li, Jindu1,2; Chen, Miao1; Yang, Shengrong1
刊名	Inorganica chimica acta
	2009-08-15
卷号	362期号:11页码:4174-4178
关键词	Peptide nucleic acid Azobenzene Ferrocene Photoisomerization Detection limit
ISSN号	0020-1693
DOI	10.1016/j.ica.2009.06.030
通讯作者	Wang, jinqing(jqwang@lzb.ac.cn)
英文摘要	In this work, three novel types of peptide nucleic acid (pna) monomers labeled by ferrocenyl-azobenzene units (fc-azo-pnas, 1a, 1b, and 1c) have been synthesized and they all exhibited good reversible photoswitch and redox properties. in the different solvents of ethanol (etoh) and acetonitrile (acn), photoisomerization rate constants (k) of three pna monomers under uv light irradiation have also been analyzed and compared, discovering that the values of k are closely correlative to their molecular structures. the electrochemical properties of the synthesized pna monomers are also investigated and the typical redox properties are displayed, demonstrating that they can be regarded as the anchor to be grafted at the end of pna oligomers for detecting themselves. finally, according to the analyses of uv-vis absorption spectrum and differential pulse voltammetry (dpv), the synthesized pna monomers afford the best detection limit down to 10 (8) m in etoh. the results also illuminate that pna monomers with new photo-redox dual stimulus-response characteristics can be realized to detect themselves by the metal complex unit together with azo moiety; moreover, the hybridization with dna also can be tuned by the isomerization of azo moiety. (c) 2009 elsevier b. v. all rights reserved.
WOS关键词	DNA DETECTION ; PNA MONOMERS ; COMPLEXES ; DYNAMICS ; THYMINE
WOS研究方向	Chemistry
WOS类目	Chemistry, Inorganic & Nuclear
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000268663900041
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2398801
专题	中国科学院大学
通讯作者	Wang, Jinqing
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Liu, Sheng,Wang, Jinqing,Li, Jindu,et al. Property and application of novel ferrocenyl-azobenzene labeled peptide nucleic acid monomers with the dual stimulus-response characteristics[J]. Inorganica chimica acta,2009,362(11):4174-4178.
APA	Liu, Sheng,Wang, Jinqing,Li, Jindu,Chen, Miao,&Yang, Shengrong.(2009).Property and application of novel ferrocenyl-azobenzene labeled peptide nucleic acid monomers with the dual stimulus-response characteristics.Inorganica chimica acta,362(11),4174-4178.
MLA	Liu, Sheng,et al."Property and application of novel ferrocenyl-azobenzene labeled peptide nucleic acid monomers with the dual stimulus-response characteristics".Inorganica chimica acta 362.11(2009):4174-4178.

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