QQ客服 官方微博 反馈留言

	The effect of collagen-binding ngf-beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model
	Sun, Wenjie1,2; Sun, Changkai3,4; Lin, Hang1; Zhao, Hui3,4; Wang, Jingyu5; Ma, Hui1,6; Chen, Bing1; Xiao, Zhifeng1; Dai, Jianwu1
刊名	Biomaterials
	2009-09-01
卷号	30期号:27页码:4649-4656
关键词	Collagen Nerve growth factor Nerve Recombinant protein Wound healing
ISSN号	0142-9612
DOI	10.1016/j.biomaterials.2009.05.037
通讯作者	Dai, jianwu(jwdai@genetics.ac.cn)
英文摘要	Nerve growth factor plays a critical role in peripheral nerve regeneration. however, the lack of efficient ngf delivery approach limits its clinical application. it has demonstrated in our previous work that the native human ngf-beta (nat-ngf) fused with a collagen-binding domain (cbd) could bind to collagen specifically. since collagen is the major component of nerve extracellular matrix, we speculated that the collagen-binding ngf would target to nerve cells and improve their regeneration. in this report, we found that the fusion protein could specifically bind to endogenous collagen of the rat sciatic nerves and maintain ngf activity both in vitro and in vivo. in the rat sciatic nerve crush injury model, we found that collagen-binding ngf could be retained and concentrated at the nerve injured site to promote nerve repair and enhance function recovery following nerve damage. thus, the collagen-binding ngf could improve the repair of peripheral nerve injury. (c) 2009 elsevier ltd. all rights reserved
WOS关键词	GROWTH-FACTOR ; PERIPHERAL-NERVE ; GENE-THERAPY ; WALLERIAN DEGENERATION ; EXTRACELLULAR-MATRIX ; NEURAL REGENERATION ; IN-VIVO ; REPAIR ; CELLS ; MANAGEMENT
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000269330400024
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2398722
专题	中国科学院大学
通讯作者	Dai, Jianwu
作者单位	1.Chinese Acad Sci, Key Lab Mol Dev Biol, Inst Genet & Dev Biol, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China 3.Dalian Med Univ, Inst Brain Disorders, Dalian 116044, Peoples R China 4.Dalian Med Univ, Key Lab Brain Disorders Liaoning Prov, Dalian 116044, Peoples R China 5.Dalian Med Univ, Ctr Expt Anim, Dalian 116044, Peoples R China 6.Dalian Med Univ, Affiliated Hosp 2, Dept Pharmaceut, Dalian 116044, Peoples R China
推荐引用方式 GB/T 7714	Sun, Wenjie,Sun, Changkai,Lin, Hang,et al. The effect of collagen-binding ngf-beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model[J]. Biomaterials,2009,30(27):4649-4656.
APA	Sun, Wenjie.,Sun, Changkai.,Lin, Hang.,Zhao, Hui.,Wang, Jingyu.,...&Dai, Jianwu.(2009).The effect of collagen-binding ngf-beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model.Biomaterials,30(27),4649-4656.
MLA	Sun, Wenjie,et al."The effect of collagen-binding ngf-beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model".Biomaterials 30.27(2009):4649-4656.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。