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	The imide-dipeptides that show strong and stable beta-sheet-like interactions compared with natural sequence
	Ke, Damei1,2; Zhan, Chuanlang1; Li, Xiao1,2; Wang, Yaobing1,2; Li, Alexander D. Q.3; Yao, Jiannian1
刊名	Tetrahedron letters
	2009-07-08
卷号	50期号:27页码:3926-3928
ISSN号	0040-4039
DOI	10.1016/j.tetlet.2009.04.067
通讯作者	Zhan, chuanlang(clzhan@iccas.ac.cn)
英文摘要	In this letter, we report solution behavior of two imide-dipeptides containing l-alanine and l-leucine residues. in contrast to natural sequence, the imide-dipeptidyl backbone contains distinct features: self-pairing h-bonds, topochemical symmetry, a peptide polindron sequence, and different orientations of side chains. the solution behavior in chloroform reveals that both the imide-dipeptides adopt beta-folding conformations and form beta-sheet-like assembly. most surprisingly, they form more stable and stronger h-bonds than the natural counterpart, and thus show different h-bonding patterns from the natural sequence. (c) 2009 elsevier ltd. all rights reserved.
WOS关键词	N,N'-LINKED OLIGOUREAS ; STRAND PEPTIDOMIMETICS ; PROTEASE INHIBITORS ; SECONDARY STRUCTURE ; NMR-SPECTROSCOPY ; AMINO-ACID ; AT-TIDES ; DESIGN ; FOLDAMERS ; PEPTIDES
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000266890000050
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2398644
专题	中国科学院大学
通讯作者	Zhan, Chuanlang
作者单位	1.Chinese Acad Sci, Inst Chem, Lab Photochem, BNLMS, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Washington State Univ, Dept Chem, Pullman, WA 99164 USA
推荐引用方式 GB/T 7714	Ke, Damei,Zhan, Chuanlang,Li, Xiao,et al. The imide-dipeptides that show strong and stable beta-sheet-like interactions compared with natural sequence[J]. Tetrahedron letters,2009,50(27):3926-3928.
APA	Ke, Damei,Zhan, Chuanlang,Li, Xiao,Wang, Yaobing,Li, Alexander D. Q.,&Yao, Jiannian.(2009).The imide-dipeptides that show strong and stable beta-sheet-like interactions compared with natural sequence.Tetrahedron letters,50(27),3926-3928.
MLA	Ke, Damei,et al."The imide-dipeptides that show strong and stable beta-sheet-like interactions compared with natural sequence".Tetrahedron letters 50.27(2009):3926-3928.

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