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	Modification of chiral stationary phases with l-proline as a selector for ligand-exchange chromatography via introducing hydrophobic groups
	Shi Hong-yu1,2; Zhang Hai-zhu1,2; Long Yuan-de1; Huang Tian-bao1
刊名	Chemical research in chinese universities
	2009-11-25
卷号	25期号:6页码:822-826
关键词	Ligand exchange chromatography Chiral stationary phase Enantioseparation Amino acid Hydroxyl acid
ISSN号	1005-9040
通讯作者	Huang tian-bao(tbhuang@cioc.ac.cn)
英文摘要	Three chiral stationary phases(csp1, csp2 and csp3) for ligand-exchange chromatography were prepared by firstly using dimethylchlorosilane as an endcapping reagent for decreasing residual silanol groups on the surface of silica gel, and then modifying the surface of silica gel with allyl glycidyl ether and alkenes through the hydrosilation reaction, and lastly introducing l-proline as a chiral selector. the enantiomer resolutions of 14 amino acids and 2 hydroxyl acids were completed on the csps by using an aqueous solution of cu(ac)(2) as mobile phase at a flow rate of 1.0 ml/min and column temperature of 40 degrees c with detection at uv 254 run. in terms of enantioselectivity alpha, column efficiency and resolution r(s), the chromatographic behaviors of the analytes on the csps were discussed via comparing them to those on the csp4 prepared via the reference method. the results show that enantioselectivity alpha, column efficiency and resolution r(s) of the analytes on the csps could be improved by using the above modifying method.
WOS关键词	LIQUID-CHROMATOGRAPHY ; AMINO-ACIDS ; RESOLUTION
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
语种	英语
出版者	HIGHER EDUCATION PRESS
WOS记录号	WOS:000272832000009
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2397921
专题	中国科学院大学
通讯作者	Huang Tian-bao
作者单位	1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Shi Hong-yu,Zhang Hai-zhu,Long Yuan-de,et al. Modification of chiral stationary phases with l-proline as a selector for ligand-exchange chromatography via introducing hydrophobic groups[J]. Chemical research in chinese universities,2009,25(6):822-826.
APA	Shi Hong-yu,Zhang Hai-zhu,Long Yuan-de,&Huang Tian-bao.(2009).Modification of chiral stationary phases with l-proline as a selector for ligand-exchange chromatography via introducing hydrophobic groups.Chemical research in chinese universities,25(6),822-826.
MLA	Shi Hong-yu,et al."Modification of chiral stationary phases with l-proline as a selector for ligand-exchange chromatography via introducing hydrophobic groups".Chemical research in chinese universities 25.6(2009):822-826.

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