QQ客服 官方微博 反馈留言

	Receptor trafficking induced by mu-opioid-receptor phosphorylation
	Zhang, Yan1; Xiong, Wei; Lin, Xiaojing; Ma, Xiang; Yu, Long-Chuan
刊名	Neuroscience and biobehavioral reviews
	2009-09-01
卷号	33期号:8页码:1192-1197
关键词	Opiates Mu-opioid receptor Phosphorylation Trafficking Tolerance Dependence G-protein coupled receptor kinase
ISSN号	0149-7634
DOI	10.1016/j.neubiorev.2009.03.007
通讯作者	Zhang, yan(yanzhang@pku.edu.cn)
英文摘要	Opiates, including morphine, are widely used drugs for antinociception in clinics. prolonged treatments of opioids induce both tolerance and dependence, which are the major side effects of opioid therapy. one of the mechanisms for the development of tolerance and dependence is implicated to be opioid-receptor trafficking. here we review the current understandings of opioid-receptor phosphorylation, endocytosis and desensitization after repeated agonist treatments. also, the role of g-protein coupled receptor kinases in opioid-receptor phosphorylation is discussed. how to associate these observations to physiological and behavioral changes in animal models and clinics is still under investigation. (c) 2009 elsevier ltd. all rights reserved.
WOS关键词	RAPID DESENSITIZATION ; CELLULAR MECHANISMS ; MORPHINE-TOLERANCE ; DOWN-REGULATION ; BETA-ARRESTIN ; OPIATE DRUGS ; SPINAL-CORD ; IN-VIVO ; AGONIST ; INTERNALIZATION
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology
WOS类目	Behavioral Sciences ; Neurosciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000270490800006
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2395804
专题	中国科学院大学
通讯作者	Zhang, Yan
作者单位	1.Peking Univ, Coll Life Sci, Neurobiol Lab, Beijing 100871, Peoples R China 2.Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yan,Xiong, Wei,Lin, Xiaojing,et al. Receptor trafficking induced by mu-opioid-receptor phosphorylation[J]. Neuroscience and biobehavioral reviews,2009,33(8):1192-1197.
APA	Zhang, Yan,Xiong, Wei,Lin, Xiaojing,Ma, Xiang,&Yu, Long-Chuan.(2009).Receptor trafficking induced by mu-opioid-receptor phosphorylation.Neuroscience and biobehavioral reviews,33(8),1192-1197.
MLA	Zhang, Yan,et al."Receptor trafficking induced by mu-opioid-receptor phosphorylation".Neuroscience and biobehavioral reviews 33.8(2009):1192-1197.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。